{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:46:26Z","timestamp":1784331986987,"version":"3.55.0"},"reference-count":79,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the last few decades there has been an alarming rise in the incidence of tumors originating at the esophagogastric junction (EGJ) [<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib1\">1<\/jats:ext-link>]. The reason for this is unknown. Tumors of the EGJ can be categorized in two types of cancer divided according to their anatomical origin: distal esophageal adenocarcinoma and adenocarcinoma of the gastric cardia. However, due to their location, in the transitional zone of the esophagus and stomach, there is constant debate about the proper classification, staging, and management of these tumors. The etiology of distal esophageal adenocarcinoma is clearly related to gastroesophageal reflux disease (GERD) and the development of a Barrett's esophagus [<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib2\">2<\/jats:ext-link>]. The etiology of adenocarcinoma of the gastric cardia is less well understood. In the present paper, we will discuss the clinical characteristics and clinical management of esophagogastric tumors. Special attention will be given to differences and similarities of adenocarcinomas of the gastric cardia and distal esophagus. J. Surg. Oncol. 2005;92:160\u2013168. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jso.20358","type":"journal-article","created":{"date-parts":[[2005,11,19]],"date-time":"2005-11-19T02:46:36Z","timestamp":1132368396000},"page":"160-168","source":"Crossref","is-referenced-by-count":52,"title":["Differences and similarities of adenocarcinomas of the esophagus and esophagogastric junction"],"prefix":"10.1002","volume":"92","author":[{"given":"W.A.","family":"Marsman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.N.J.","family":"Tytgat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.J.W.","family":"Ten Kate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.B.","family":"van Lanschot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981115)83:10<2049::AID-CNCR1>3.0.CO;2-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903183401101"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197203)29:3<724::AID-CNCR2820290328>3.0.CO;2-5"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0016-5085(84)80016-5","article-title":"Clinical, epidemiologic, and morphologic comparison between adenocarcinomas arising in Barrett's esophageal mucosa and in the gastric cardia","volume":"86","author":"Kalish RJ","year":"1984","journal-title":"Gastroenterology"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90217-8"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091920106"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200003000-00009"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04053.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01930.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-190608000-00009"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18003815005"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.8.2.87"},{"key":"e_1_2_1_14_2","first-page":"881","article-title":"The lower esophagus lined by columnar epithelium","volume":"41","author":"Barrett NR","year":"1957","journal-title":"Surgery"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05910.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01359557"},{"key":"e_1_2_1_17_2","first-page":"173","article-title":"Carcinoma of the gastroesophageal junction\u2014classification, pathology and extent of resection","volume":"9","author":"Siewert JR","year":"1996","journal-title":"Dis Esophagus"},{"key":"e_1_2_1_18_2","first-page":"25","article-title":"[Cardia cancer: attempt at a therapeutically relevant classification]","volume":"58","author":"Siewert JR","year":"1987","journal-title":"Chirurg"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.1998.91363"},{"key":"e_1_2_1_20_2","volume-title":"TNM classification of malignant tumors","author":"Sobin LH","year":"2002"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197904)43:4<1557::AID-CNCR2820430450>3.0.CO;2-L"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(97)00129-4"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10940"},{"key":"e_1_2_1_24_2","first-page":"542","article-title":"[Does incidence of carcinoma of the esophagogastric junction increase?]","volume":"99","author":"Ozawa S","year":"1998","journal-title":"Nippon Geka Gakkai Zasshi"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200202000-00003"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i6.1156"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601737"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04131.x"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90847-X"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008913828105"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.2.150"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-11-199906010-00003"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11568"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0288"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.3.297"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01758.x"},{"key":"e_1_2_1_37_2","first-page":"588","article-title":"An inverse relation between cagA+ strains of Helicobacter pylori infection and risk of esophageal and gastric cardia adenocarcinoma","volume":"58","author":"Chow WH","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70364-6"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00523.x"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh057"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.7.938"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10887"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1309\/N15U-FN5R-3M5D-PE0U"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200003000-00002"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70576-1"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02000.x"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19961104)68:3<300::AID-IJC6>3.0.CO;2-5"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1992.52"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.2.104"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(95)03786-V"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.8.1095"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32963"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21171"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(88)90024-5"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.17.1277"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.16507"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0839"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000322"},{"key":"e_1_2_1_59_2","first-page":"748","article-title":"Comparative genomic hybridization of cancer of the gastroesophageal junction: Deletion of 14Q31\u201032.1 discriminates between esophageal (Barrett's) and gastric cardia adenocarcinomas","volume":"59","author":"van Dekken H","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33580"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.12.1678"},{"key":"e_1_2_1_62_2","first-page":"97","article-title":"Use of aspirin and other nonsteroidal anti\u2010inflammatory drugs and risk of esophageal and gastric cancer","volume":"7","author":"Farrow DC","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.16482"},{"key":"e_1_2_1_64_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2003.01724.x"},{"key":"e_1_2_1_65_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.1.9"},{"key":"e_1_2_1_66_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200003000-00003"},{"key":"e_1_2_1_67_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2001.110024"},{"key":"e_1_2_1_68_2","first-page":"247","article-title":"Lymphatic drainage routes of the gastric cardia visualized by lymphoscintigraphy","volume":"45","author":"Cense HA","year":"2004","journal-title":"J Nucl Med"},{"key":"e_1_2_1_69_2","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2000.110722"},{"key":"e_1_2_1_70_2","doi-asserted-by":"publisher","DOI":"10.1159\/000068360"},{"key":"e_1_2_1_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)01312-4"},{"key":"e_1_2_1_72_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1005599"},{"key":"e_1_2_1_73_2","first-page":"421","article-title":"Laparoscopy and laparoscopic ultrasonography in staging of carcinoma of the esophagus and gastric cardia","volume":"181","author":"Bemelman WA","year":"1995","journal-title":"J Am Coll Surg"},{"key":"e_1_2_1_74_2","doi-asserted-by":"publisher","DOI":"10.1080\/110241500447245"},{"key":"e_1_2_1_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970401)79:7<1315::AID-CNCR7>3.0.CO;2-F"},{"key":"e_1_2_1_76_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200009000-00007"},{"key":"e_1_2_1_77_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1999.01082.x"},{"key":"e_1_2_1_78_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02303497"},{"key":"e_1_2_1_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)02570-4"},{"key":"e_1_2_1_80_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022343"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.20358","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.20358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T08:54:37Z","timestamp":1694508877000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.20358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,18]]},"references-count":79,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1002\/jso.20358"],"URL":"https:\/\/doi.org\/10.1002\/jso.20358","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,18]]}}}