{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T23:49:19Z","timestamp":1787356159165,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,26]],"date-time":"2007-02-26T00:00:00Z","timestamp":1172448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2007,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Solid pseudopapillary tumors (SPTs) represent one of the most uncommon histotypes of all exocrine pancreatic neoplasms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To delineate the clinical presentation and biological behavior of SPT and evaluate the efficacy of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of 31 patients (27 female, 4 male, mean age of 34 years, (range 7\u201356)) who underwent surgical resection with a definitive histological diagnosis of SPT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tumor detection was incidental in the 55% of cases. Symptoms were abdominal discomfort (n\u2009=\u200910), jaundice (n\u2009=\u20092), weight loss (n\u2009=\u20096), vomiting (n\u2009=\u20095), and a palpable abdominal mass (n\u2009=\u20094). The neoplasm was localized in the pancreatic head in 10 patients and in the body\u2010tail in 20 cases; the main diameter ranged from 2 to 20 cm (mean 5.4). At the radiological work\u2010up, the neoplasm was solid in 87% of cases and delimited by a capsule in 39%. An internal necrotic\u2010hemorrhagic area was present in 29% of cases. Calcifications were noticed in two patients and septa in one. None of the patients had metastases at the time of diagnosis. In 9 cases, pancreaticoduodenectomy was performed, while 15 patients underwent a left pancreatectomy (4 spleen preserving), 6 a middle pancreatectomy, and 1 enucleation. There was no postoperative mortality with an overall morbidity of 35%. At a median follow\u2010up of 58.2 months (12\u2013229 range), all patients are alive without evidence of local recurrence, metastasis, diabetes, or exocrine insufficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Solid pseudopapillary tumor (SPT) is an indolent neoplasm with low\u2010grade biological aggressiveness, making surgical treatment successful despite its large size. J. Surg. 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