{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:59:48Z","timestamp":1791557988026,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T00:00:00Z","timestamp":1168905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The presence of extranodal invasion (ENI) in the metastatic lymph nodes is reported to increase the risk of locoregional recurrence while shortening disease\u2010free and overall survival in patients with breast cancer. In this study the relationship between ENI and other prognostic parameters and survival is investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of 650 patients with breast cancer who were treated in Ankara Oncology Teaching and Research Hospital from 1996 to 2003, 368 (56.6%) had lymph node metastasis. The patients with axillary metastasis were separated into two groups as with and without invasion to lymph node capsule and the surrounding adipose tissue. Clinicopathologic features were analyzed by univariate and multivariate logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 368 patients with axillary metastasis, 135 (36.7%) had ENI. Based on multivariate analysis; the number of metastatic lymph nodes, lymphatic invasion, and tumor necrosis were found to be related with ENI. In the group with ENI, 5\u2010year overall survival rate was 74.8%, compared to 82.3% for patients without ENI which was significantly lower (<jats:italic>P<\/jats:italic>\u2009=\u20090.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In lymph node positive breast cancer with presence of ENI, adverse prognostic parameters are more frequently encountered and has a worse overall survival compared to group without ENI. J. Surg. Oncol. 2007;95:567\u2013571. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.20758","type":"journal-article","created":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T00:35:43Z","timestamp":1168994143000},"page":"567-571","source":"Crossref","is-referenced-by-count":21,"title":["The correlation of extranodal invasion with other prognostic parameters in lymph node positive breast cancer"],"prefix":"10.1002","volume":"95","author":[{"given":"H\u00fcseyin","family":"Altinyollar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U\u011fur","family":"Berbero\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaptan","family":"G\u00fclben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fikret","family":"\u0130rkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711390312"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/ajcp\/111.1.21","article-title":"Prognostic features in patients with stage T1 breast carcinoma and a 0.5 cm or less lymph node metastasis","volume":"111","author":"Goldstein NS","year":"1999","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2001.1173"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00424-1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/ajcp\/65.4.439","article-title":"Pathologic findings from the National Surgical Adjuvant Breast project. 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