{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:15:08Z","timestamp":1791166508849,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,4,18]],"date-time":"2007-04-18T00:00:00Z","timestamp":1176854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>High intensity focused ultrasound (HIFU) is a non\u2010invasive technique for tumor ablation. The goal of this study was to investigate the feasibility of performing wide local ablation using ultrasound\u2010guided HIFU in the treatment of patients with localized breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010three patients with histologically proven breast cancer were enrolled in this prospective clinical trial. They underwent HIFU treatment for breast cancer including the tumor and 1.5\u20132.0 cm normal breast tissue surrounding the tumor, followed by modified mastectomy 1\u20132 weeks after HIFU. Radiological examination, histological, and terminal deoxynucleotidyl transferase\u2010mediated nick end labeling (TUNEL) methods were performed to evaluate therapeutic effects in the treated region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thermal ablation was confirmed in all 23 patients. It included tumor and normal breast tissue surrounding the tumor. Mean values of the largest parallel and perpendicular dimensions, and volume of HIFU lesions in excised breasts were significantly larger than those of the targeted tumors respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Hematoxylin and eosin (H &amp; E) staining showed clear evidence of complete coagulation necrosis in the treated regions. However, no apoptotic cells were detected in either treated tumor or normal breast tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As a non\u2010invasive therapy, ultrasound\u2010guided HIFU can induce wide local ablation in the treatment of patients with localized breast cancer. J. Surg. Oncol. 2007;96:130\u2013136. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.20769","type":"journal-article","created":{"date-parts":[[2007,4,18]],"date-time":"2007-04-18T23:20:34Z","timestamp":1176938434000},"page":"130-136","source":"Crossref","is-referenced-by-count":64,"title":["\u201cWide local ablation\u201d of localized breast cancer using high intensity focused 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