{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:09:43Z","timestamp":1790935783305,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,10,10]],"date-time":"2007-10-10T00:00:00Z","timestamp":1191974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>False\u2010negative mammograms may result in a delay in breast carcinoma diagnosis and have important implications for patient care. In this study, the characteristics of symptomatic patients with false\u2010negative mammograms were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with symptomatic breast carcinoma were identified over a 10\u2010year period (1994\u20132004). One hundred and twenty\u2010four patients had false\u2010negative preoperative mammograms and 1241 patients had abnormal preoperative mammograms. Clinical presentation, diagnostic methods and pathology were analysed. False\u2010negative mammograms were reviewed by a specialist breast radiologist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following retrospective review, 42% of false\u2010negative mammograms were re\u2010categorised as suspicious. The most commonly misinterpreted lesion was architectural distortion\/asymmetrical density. Adjuvant ultrasound, where performed (n\u2009=\u200927), raised the level of suspicion in 93% of cases. Patients with false\u2010negative mammograms were more likely to be younger (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), present with nipple discharge (<jats:italic>P<\/jats:italic>\u2009=\u20090.002) and have smaller tumours (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Their tumours were more frequently located outside the upper outer quadrant (<jats:italic>P<\/jats:italic>\u2009=\u20090.002). False\u2010negative mammography led to a delay in diagnosis of &gt;2 months in 12 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Symptomatic patients with false\u2010negative mammograms often demonstrate definite abnormalities on imaging, the most common of which is architectural distortion\/asymmetrical density. Those at particular risk were younger patients, those with nipple discharge, and patients with lesions located outside the upper outer quadrant. J. Surg. 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