{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T21:46:50Z","timestamp":1785793610528,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,11,29]],"date-time":"2007-11-29T00:00:00Z","timestamp":1196294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Parosteal osteosarcoma is a rare type of osteosarcoma with distinct characteristics. Clinical outcome of 21 patients was analyzed to assess the predictive relevance of surgical margin, intramedullary tumor extension and histologic grade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>There were 5 mens and 16 womens with an average age of 26 years. Average follow\u2010up was 9.1 years (range 2.5\u201322.1). Most common sites were distal femur (15) and proximal humerus (2). No patient presented with metastasis. Surgical margin was wide in 13 and marginal in 8. Intramedullary extension was seen in 10 patients (48%). Focal high\u2010grade 2 and 3 tumors were seen in 11 (52%) and 3 (14%) patients respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients (95%) were alive without disease. Two (10%) had relapse, one with local recurrence and another with local recurrence and lung metastasis. Of eight marginal procedures performed, 2 turned out to have histologically tumor\u2010positive margins, both of whom later developed relapses. All patients with histologically negative margins remained disease\u2010free. Presence of intramedullary extension and focal high\u2010grade tumor was not significantly associated with relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A marginal but histologically negative margin of excision appears adequate for parosteal osteosarcoma. However, long\u2010term follow\u2010up is warranted for monitoring of rare incidences of local recurrences or distant metastases. J. Surg. Oncol. 2008;97:146\u2013149. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.20902","type":"journal-article","created":{"date-parts":[[2007,11,29]],"date-time":"2007-11-29T19:46:55Z","timestamp":1196365615000},"page":"146-149","source":"Crossref","is-referenced-by-count":33,"title":["Clinical outcome of parosteal osteosarcoma"],"prefix":"10.1002","volume":"97","author":[{"given":"Ilkyu","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Han","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Gon","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Chul","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195106000-00006"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2106\/00004623-196749030-00001","article-title":"Juxtacortical osteosarcoma; Diagnosis, differential diagnosis, treatment and an analysis of eighty cases","volume":"49","author":"Heul V","year":"1967","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"732","DOI":"10.2106\/00004623-195436040-00004","article-title":"Parosteal (juxtacortical) osteogenic sarcoma","volume":"36","author":"Dwinnell LA","year":"1954","journal-title":"J Bone Joint Surg Am"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2106\/00004623-198567010-00016","article-title":"The surgical treatment of parosteal osteosarcoma in long bones","volume":"67","author":"Enneking W","year":"1985","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453679108993592"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1302\/0301-620X.66B3.6586725","article-title":"Parosteal osteosarcoma","volume":"66","author":"Campanacci M","year":"1984","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1302\/0301-620X.72B6.2246298","article-title":"Parosteal osteosarcoma. 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