{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:30:39Z","timestamp":1780489839974,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,12,27]],"date-time":"2007-12-27T00:00:00Z","timestamp":1198713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Bone metastases are typically treated with bisphosphonates as adjuncts to radiation therapy. The goal of this study was to determine whether radiotherapy combined with a bisphosphonate could restore bone density, microarchitecture, and biomechanical strength of a tumor\u2010burdened bone to normal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Breast cancer cells were injected into the right femur of 30 female nude mice. Mice were divided into three treatment groups (0 Gy, 20 Gy, and 20 Gy\u2009+\u2009ZA). Left limbs served as non\u2010operated normal bones. Tumor\u2010bearing femora were irradiated 3 weeks later. ZA (100 \u00b5g\/kg SC) was administered once weekly for 6 weeks. Mice were euthanized at 9 weeks or earlier if severe lameness or pathology occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mice treated with 20 Gy\/ZA exhibited higher bone density, bone volume, fractional trabecular bone volume, and biomechanical strength compared to mice treated with 20 Gy only (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Statistical analysis revealed that mice treated with 20 Gy\/ZA were not significantly different from normal bones with respect to bone density and strength. Micro\u2010CT reconstructions showed improved microarchitecture in the 20 Gy\/ZA group compared to 20 Gy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment of an osteolytic bone with radiation therapy plus zoledronic acid restores normal bone qualities with respect to bone density, microarchitecture, and biomechanical strength. J. Surg. Oncol. 2008;97:284\u2013290. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.20949","type":"journal-article","created":{"date-parts":[[2007,12,27]],"date-time":"2007-12-27T20:19:24Z","timestamp":1198786764000},"page":"284-290","source":"Crossref","is-referenced-by-count":38,"title":["Concurrent administration of zoledronic acid and irradiation leads to improved bone density, biomechanical strength, and microarchitecture in a mouse model of tumor\u2010induced osteolysis"],"prefix":"10.1002","volume":"97","author":[{"given":"Sarah A.","family":"Arrington","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Damron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A.","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,27]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-3-227"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-5-89"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-005-0913-5"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3816\/CBC.2000.n.003"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.116"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.09.013"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4508"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.8.1486"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215549704500215"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1667\/RR3108"},{"key":"e_1_2_1_12_2","first-page":"282","article-title":"Metastatic breast cancer in the femur. A search for the lesion at risk of fracture","volume":"1986","author":"Keene JS","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820901)50:5<893::AID-CNCR2820500515>3.0.CO;2-Y"},{"key":"e_1_2_1_14_2","first-page":"297","article-title":"Fracture healing in metastatic bone disease","volume":"1983","author":"Gainor BJ","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_1_15_2","first-page":"S158","article-title":"General principles of external beam radiation therapy for skeletal metastases","volume":"2003","author":"Frassica DA","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_1_16_2","first-page":"256","article-title":"Metastatic disease in long bones. A proposed scoring system for diagnosing impending pathologic fractures","volume":"1989","author":"Mirels H","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11646"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.82B1.9483"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(01)00644-5"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.12.3890"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.20949","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.20949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T23:42:11Z","timestamp":1700005331000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.20949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,27]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1002\/jso.20949"],"URL":"https:\/\/doi.org\/10.1002\/jso.20949","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,27]]}}}