{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T15:31:34Z","timestamp":1771255894791,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,12,28]],"date-time":"2007-12-28T00:00:00Z","timestamp":1198800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Present surgical opinion is divided regarding the optimal method for the treatment of duodenal gastrointestinal stromal tumor (GIST) with some supporting the selective use of limited resection (LR) versus others who prefer pancreaticoduodenectomy (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of 22 patients who underwent surgery for suspected GIST involving the duodenum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 15 GISTs, 1 leiomyosarcoma and 6 other non\u2010GIST benign submucosal tumors. Seven patients underwent LR and seven underwent PD for GIST. The median follow\u2010up was 42 (range, 2\u2013174) months. Patients who underwent LR versus PD had similar mean disease\u2010specific survival [144 (95% CI, 92\u2013196) vs. 130 (95% CI, 82\u2013127) months, <jats:italic>P<\/jats:italic>\u2009=\u20090.808] and recurrence rates (14% vs. 29%, <jats:italic>P<\/jats:italic>\u2009=\u20090.515). All recurrences occurred at distant sites. Comparison between LR versus PD demonstrated that LR was associated with a significantly shorter operation time [125 (range, 50\u2013305) vs. 350 (range, 210\u2013465) min., <jats:italic>P<\/jats:italic>\u2009=\u20090.001] but similar morbidity rate (23% vs. 43%, <jats:italic>P<\/jats:italic>\u2009=\u20090.357). Comparison between GIST and other benign tumors demonstrated that size was the only statistically significant distinguishing factor [8.5 (range, 2.5\u201318.0) vs. 2.5 (range, 1.5\u20138.0) cm, <jats:italic>P<\/jats:italic>\u2009=\u20090.014].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Benign non\u2010GIST tumors may be distinguished from duodenal GIST as they are smaller in size. LR is a viable treatment option for suspected GIST involving the duodenum. J. Surg. 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