{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T12:01:52Z","timestamp":1771848112921,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,1,30]],"date-time":"2008-01-30T00:00:00Z","timestamp":1201651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Lymph\u2010node dissection in gastric cancers with esophageal invasion (AGCE) is of current interest. This study examined the significance of inferior mediastinal lymph\u2010node (IM) and para\u2010aortic lymph\u2010node (PA) dissection for this type of cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Two hundred and seventy cases of AGCE were clinicopathologically reviewed. An index of estimated benefit from lymph\u2010node dissection (IEBLD) was calculated from the frequency of lymph node metastasis in IM and PA, and from 5\u2010year survival rates for metastatic cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the cases of AGCE, IM and PA metastasis rates were 18.1% and 22.2%, respectively. The IEBLD for IM and PA was similar to that for dissection of the second\u2010tier lymph nodes around the celiac axis. The IM metastasis rate was 0.0% for esophageal invasion of 0\u20139\u2009mm, 2.2% for 10\u201319\u2009mm, 17.8% for 20\u201329\u2009mm, and 21.7% for 30\u201339\u2009mm of esophageal invasion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AGCE is associated with a high rate of PA metastasis, and with a high rate of IM metastasis when esophageal invasion exceeds 2\u2009cm. Since dissection of IM and PA achieved the same benefit as dissection of second\u2010tier lymph nodes, we recommend thorough dissection of these lymph nodes. J. Surg. Oncol. 2008;97:392\u2013395. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.20987","type":"journal-article","created":{"date-parts":[[2008,1,30]],"date-time":"2008-01-30T17:19:31Z","timestamp":1201713571000},"page":"392-395","source":"Crossref","is-referenced-by-count":28,"title":["Benefit of mediastinal and para\u2010aortic lymph\u2010node dissection for advanced gastric cancer with esophageal invasion"],"prefix":"10.1002","volume":"97","author":[{"given":"Souya","family":"Nunobe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigekazu","family":"Ohyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sonoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Hiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsu","family":"Fukunaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Seto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,30]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2003.95"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1427"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(89)90305-X"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01655060"},{"key":"e_1_2_1_6_2","unstructured":"World Health OrganizationFact sheet N 297http:\/\/www.who.int\/mediacentre\/factsheets\/fs297\/en\/index html."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055531"},{"key":"e_1_2_1_8_2","unstructured":"SasakoM YamaguchiT KinoshitaT et al.:Randomized phase III trial comparing S\u20101 monotherapy versus surgery alone for stage II\/III gastric cancer patients after curative D2 gastrectomy (ACTS\u2010GC study). 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