{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:18:19Z","timestamp":1784128699994,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,3,3]],"date-time":"2008-03-03T00:00:00Z","timestamp":1204502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Intraductal papillary neoplasm of the bile ducts (IPN\u2010B) is considered an uncommon tumor. The purpose of this study was to evaluate the clinical, radiological, and histopathological characteristics of IPN\u2010B, and its prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From October 1995 to August 2006, a retrospective analysis was made of 25 patients that underwent surgery for IPN\u2010B. Clinical features and radiological, pathological, and operative findings were reviewed, and survival rates were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In five patients (20.0%), lesions were incidentally found. Radiologically, 23 of the 25 (92.0%) showed bile duct dilatation, bile duct dilatation with or without an intraductal mass, and cystic changes of bile ducts. Twenty three of the 25 patients underwent hepatic resection with or without extrahepatic bile duct resection. No in hospital mortality occurred. Median survival time of resected patients was 59.8 months and 1\u2010, 2\u2010, and 4\u2010year survival rates were 90.5%, 84.0%, and 84.0%, respectively. All six patients with benign IPN\u2010B remained alive at a mean of 26.2 postoperative months without recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A diagnosis of IPN\u2010B is usually made in patients with biliary dilatation by radiologic study. The prognosis of IPN\u2010B, especially of the benign category, is excellent. Aggressive surgical resection is the treatment of choice for IPN\u2010B. J. Surg. Oncol. 2008;97:508\u2013512. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.20994","type":"journal-article","created":{"date-parts":[[2008,3,3]],"date-time":"2008-03-03T18:18:48Z","timestamp":1204568328000},"page":"508-512","source":"Crossref","is-referenced-by-count":58,"title":["Intraductal papillary neoplasm of the bile ducts: The clinical features and surgical outcome of 25 cases"],"prefix":"10.1002","volume":"97","author":[{"given":"Kwang Yeol","family":"Paik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Seok","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Wook","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,3,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005340050092"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310104"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007290"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1001418"},{"key":"e_1_2_1_6_2","first-page":"173","volume-title":"World health organization classification of tumours pathology and genetics of tumours of the digestive system","author":"Nakanuma Y","year":"2000"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20031"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199801000-00010"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21387"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.09.025"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200403000-00005"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.28199"},{"key":"e_1_2_1_13_2","first-page":"851","article-title":"Biliary papillary neoplasm of the liver","volume":"17","author":"Nakanuma Y","year":"2002","journal-title":"Histol Histopathol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000160817.94472.fd"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2004.04.028"},{"key":"e_1_2_1_16_2","first-page":"477","article-title":"Mutation of p53 and K\u2010ras, and loss of heterozygosity of APC in intrahepatic cholangiocarcinoma","volume":"79","author":"Kang YK","year":"1999","journal-title":"Lab Invest"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1572-0241.2003.04025.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880409"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20837"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000217636.40050.54"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.03242.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800643"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpa.0000153615.55761.00"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.20994","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.20994","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T07:48:25Z","timestamp":1700034505000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.20994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,3]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1002\/jso.20994"],"URL":"https:\/\/doi.org\/10.1002\/jso.20994","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,3]]}}}