{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:36:42Z","timestamp":1778056602095,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,7,30]],"date-time":"2008-07-30T00:00:00Z","timestamp":1217376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The role of human nonmetastatic clone 23 type 1 (nm23\u2010H1), a metastasis\u2010associated gene, is less clear\u2010cut in cancer of uterine cervix; therefore, we investigate its expression in cancer tissues and its correlation with clinicopathologic variables and survival of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty cervical cancer tissues and their normal counterparts were collected to evaluate quantitative nm23\u2010H1 mRNA expression. From them, 16 cancer and 16 normal tissues were collected and added with another 64 cancer tissues to construct a 96\u2010tissue core microarray for immunohistochemical study. We evaluated the relationships among nm23\u2010H1 immunostaining using semi\u2010quantitative H scores, clinicopathologic parameters, recurrence and survival in cervical cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nm23\u2010H1 mRNA expression and H score (median H scores: 2.0 vs. 0.3, <jats:italic>P<\/jats:italic>\u2009=\u20090.001) were higher in cervical cancer tissues than normal counterparts, respectively. Nm23\u2010H1 expression was significantly associated with depth of stromal invasion (<jats:italic>P<\/jats:italic>\u2009=\u20090.003), tumor diameter (<jats:italic>P<\/jats:italic>\u2009=\u20090.044) and cell differentiation (<jats:italic>P<\/jats:italic>\u2009=\u20090.025). Other than stage II, poor cell differentiation as well as positive parametrium invasion and lymph node metastasis, positive nm23\u2010H1 expression was significantly correlated with poor overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High nm23\u2010H1 expression is predictive of worse overall survival for cervical cancer patients. J. Surg. Oncol. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.21127","type":"journal-article","created":{"date-parts":[[2008,7,30]],"date-time":"2008-07-30T18:37:17Z","timestamp":1217443037000},"page":"448-456","source":"Crossref","is-referenced-by-count":11,"title":["High expression of human nonmetastatic clone 23 type 1 in cancer of uterine cervix and its association with poor cell differentiation and worse overall survival"],"prefix":"10.1002","volume":"98","author":[{"given":"Chien\u2010Gang","family":"Hsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long\u2010Yau","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiunn\u2010Liang","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun\u2010Fa","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Yi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu\u2010Ting","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiuan\u2010Chih","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po\u2010Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,30]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/80.3.200"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/342177a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.14.1199"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)55460-0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005584929050"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023497924277"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(98)00087-9"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20050269"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2005.02.004"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981215)83:12<2481::AID-CNCR11>3.0.CO;2-P"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/00313029600169014"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.017954"},{"key":"e_1_2_1_14_2","first-page":"855","article-title":"Evidence 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