{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T19:08:09Z","timestamp":1767035289169},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,9,2]],"date-time":"2008-09-02T00:00:00Z","timestamp":1220313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Post\u2010gastrectomy recurrences of early gastric cancer occur in a few cases. We investigated the outcome of early gastric cancer patients treated surgically, with special respect to the risk factor(s) for tumor recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>A total of 308 patients with mono\u2010foci early gastric cancer underwent curative surgical resection. Clinicopathological variables and tumor recurrence patterns were analyzed retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recurrence was observed in 30 out of 245 patients (12.24%) who had completed follow\u2010up. The median interval from surgery to diagnosis of recurrence was 28 (range 3\u2013188) months. Hematogenous recurrence (3.27%) was twice as frequent as peritoneal recurrence (1.63%). Gastric stump cancer occurred in 9 patients (3.67%), anastomotic recurrence in 7 patients (2.86%) and lymphatic recurrence in 4 patients (1.63%). Older patients (\u226560 years old) had a more frequent recurrence rate than younger patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Multivariate analyses identified lymph node metastasis and depth of invasion as risk factors of recurrence. All the patients with a positive family history of cancer got recurrence within 3 years after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early gastric cancer patients, who were elderly, had lymphatic and submucosal involvement, and patients with a positive family history of cancer, tended to have a greater risk of recurrence. J. Surg. Oncol. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.21133","type":"journal-article","created":{"date-parts":[[2008,9,2]],"date-time":"2008-09-02T14:41:41Z","timestamp":1220366501000},"page":"411-414","source":"Crossref","is-referenced-by-count":41,"title":["Recurrence in patients following curative resection of early gastric carcinoma"],"prefix":"10.1002","volume":"98","author":[{"given":"Benyan","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daohong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gangshi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,9,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01358.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02468883"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.2.142"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/110241599750006848"},{"key":"e_1_2_1_6_2","first-page":"53","article-title":"Pathomorphological diagnosis. 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