{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T11:20:50Z","timestamp":1785583250566,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T00:00:00Z","timestamp":1227052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Many surgeons perceive total pancreatectomy (TP) for pancreatic adenocarcinoma to be associated with inferior outcomes compared to partial pancreatectomy (PP), such as pancreaticoduodenectomy (PD) and distal pancreatectomy (DP). We sought to analyze peri\u2010operative mortality and long\u2010term survival following TP versus PP for pancreatic adenocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Surveillance, Epidemiology, and End Results (SEER) database was used to identify patients with resected pancreatic adenocarcinoma (1998\u20132004). Survival after TP versus PP was compared by tumor location.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 3280 patients with resected pancreatic head tumors, 292 underwent TP, and 2988 PD. One\u2010month mortality was 9.0% for TP and 6.5% for PD (<jats:italic>P<\/jats:italic>= 0.11). Of 315 patients with resected body\/tail tumors, 32 underwent TP, and 283 DP. One\u2010month mortality was 9.3% for TP and 3.9% for DP (<jats:italic>P<\/jats:italic>= 0.17). Of 426 patients with resected tumors in unspecified pancreatic locations, 52 underwent TP, and 374 PP. One\u2010month mortality was 5.8% for TP and 6.5% for PP (<jats:italic>P<\/jats:italic>= 0.87). Survival analyses demonstrated no difference between TP and PP (hazard ratio (HR) 1.06,<jats:italic>P<\/jats:italic>= 0.49 for head; HR 0.84,<jats:italic>P<\/jats:italic>= 0.51 for body\/tail; HR 1.06,<jats:italic>P<\/jats:italic>= 0.79 for unspecified locations).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Peri\u2010operative mortality and long\u2010term survival are similar following TP versus PP for pancreatic adenocarcinoma, supporting the use of TP when oncologically appropriate. J. Surg. Oncol. 2009;99: 87\u201392. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.21189","type":"journal-article","created":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T18:50:14Z","timestamp":1227120614000},"page":"87-92","source":"Crossref","is-referenced-by-count":70,"title":["Peri\u2010operative mortality and long\u2010term survival after total pancreatectomy for pancreatic adenocarcinoma: A population\u2010based perspective"],"prefix":"10.1002","volume":"99","author":[{"given":"Hari","family":"Nathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Wolfgang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barish H.","family":"Edil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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