{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:53:40Z","timestamp":1775267620989,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,2,18]],"date-time":"2009-02-18T00:00:00Z","timestamp":1234915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to examine whether a relationship exists between HIF\u20101\u03b1 expression and the pro\u2010apoptotic protein p53 in supraglottic laryngeal squamous cell carcinomas (SCCs), which could provide information concerning patient prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population was composed of 106 previously untreated men with SCC of the supraglottic larynx. All the patients underwent surgical resection of the tumor and bilateral neck dissection. Immunohistochemical analysis of HIF\u20101\u03b1 and p53 protein expression was performed in relation with clinicopathological parameters and prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HIF\u20101\u03b1 nuclear expression was detected in 71% of primary carcinomas and 55% of the paired lymph node metastases. There was a significant positive correlation between HIF\u20101\u03b1 and T\u2010classification but no associations were observed with other clinicopathological variables and with prognosis. There was no correlation between the expression of HIF\u20101\u03b1 and p53. HIF\u20101\u03b1 overexpression in combination with p53 immunostaining was not associated with disease recurrence or survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The data suggest that HIF\u20101\u03b1 expression does not have a prognostic value in surgically treated supraglottic laryngeal SCC, and that immunohistochemical determination of p53 does not allow improving the clinical significance of HIF\u20101\u03b1. J. Surg. Oncol. 2009;99:373\u2013378. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.21243","type":"journal-article","created":{"date-parts":[[2009,2,18]],"date-time":"2009-02-18T13:50:41Z","timestamp":1234965041000},"page":"373-378","source":"Crossref","is-referenced-by-count":18,"title":["The relation between hypoxia\u2010inducible factor (HIF)\u20101alpha expression with p53 expression and outcome in surgically treated supraglottic laryngeal 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