{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:12:03Z","timestamp":1788354723133,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,3,27]],"date-time":"2009-03-27T00:00:00Z","timestamp":1238112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The goal of the current study is to identify predictors responsible for mortality disparities between young (\u226440 years) and older (&gt;40 years) women with breast cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From 1998 to 2006, 344 patients \u226440 years were treated for breast cancer. Cox regression models calculated adjusted hazard ratios (aHR) and 95% confidence intervals (CI) to determine differences in breast cancer mortality in women \u226440 years versus &gt;40 years (n\u2009=\u20093,252), controlling for potential confounders in univariate tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 1998 to 2006, 3,596 patients were treated for breast cancer; 9.6% were \u226440 years and 90.4% were &gt;40 years. Young women were more likely to be African\u2010American, with a family history of breast cancer, diagnosed at advanced stage, and treated by mastectomy (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Tumors in young women were more likely to be bilateral, T2\/T3, grade III, ER\/PR negative, and lymph\u2010node positive (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Overall, young women (\u226440 years) with breast cancer were more likely to die compared with older women (&gt;40 years) (aHR 1.52, CI 1.37\u20131.74).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Young women (\u226440 years) with breast cancer are diagnosed at a more advanced stage and have tumors with poor prognostic features. Young women (\u226440 years) are 52% more likely to die from breast cancer compared to older women (&gt;40 years). J. Surg. Oncol. 2009;100:248\u2013251. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.21268","type":"journal-article","created":{"date-parts":[[2009,3,30]],"date-time":"2009-03-30T08:29:19Z","timestamp":1238401759000},"page":"248-251","source":"Crossref","is-referenced-by-count":128,"title":["Patient and tumor characteristics associated with increased mortality in young women (\u226440 years) with breast cancer"],"prefix":"10.1002","volume":"100","author":[{"given":"Ankit","family":"Bharat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Aft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Margenthaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,27]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.56.3.168"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980915)83:6<1262::AID-CNCR28>3.0.CO;2-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960101)77:1<97::AID-CNCR16>3.0.CO;2-3"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00917-6"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02967527"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1309\/8941VDAJMKY2GCLX"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900415)65:8<1867::AID-CNCR2820650833>3.0.CO;2-I"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19961015)78:8<1838::AID-CNCR27>3.0.CO;2-Y"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198608283150906"},{"key":"e_1_2_1_11_2","article-title":"Elevated breast cancer mortality in women younger than age 40 years compared with older women is attributed to poorer survival in early\u2010stage disease","author":"Gnerlich J","journal-title":"JACS"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191367098"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1732912100"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.21.2492"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl145"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.3754"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.21268","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.21268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.21268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T13:33:14Z","timestamp":1699882394000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.21268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,27]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1002\/jso.21268"],"URL":"https:\/\/doi.org\/10.1002\/jso.21268","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,27]]}}}