{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:08:21Z","timestamp":1791094101888,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:00:00Z","timestamp":1240272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is a dearth of data in a younger population of patients with pancreatic ductal adenocarcinoma (PAC) regarding epidemiology, genetics, prognosis, and outcome. This report examines a large cohort of patients with PAC \u226445 years of age evaluated at MSKCC over a 12\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of patients referred to MSKCC with PAC identified from the institutional tumor registry, who were \u226445 years on the date of the diagnostic biopsy, between January 1995 and February 2008, was performed. Information reviewed included demographics, clinical and pathological staging, surgical management, therapy, date of relapse, death or last follow\u2010up. Survival curves were estimated using the Kaplan\u2013Meier method and compared using the log\u2010rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred thirty\u2010six cases of PAC, age \u226445 years at diagnosis, were identified. Seventy\u2010four (54%) females, 62 (46%) males. Age range: 24\u201345; 4, 38, and 94 patients in age groups 20\u201329, 30\u201339, 40\u201345 years, respectively. Fifty (37%) had a smoking history. Fourteen (10.3%) had a positive family history of PAC. Thirty\u2010five (25.7%) underwent a curative resection for localized disease. Twenty\u2010eight (20.1%) presented with locally advanced, inoperable disease. Sixty\u2010eight (50%) presented as AJCC Stage IV. Twenty\u2010three (37%) of those resected underwent adjuvant chemoradiation. Thirteen received adjuvant gemcitabine. The median overall survival for the entire cohort was 12.3 months (95% CI 10.2\u201314.0 months). The median overall survival for the patients with locally resectable disease was 41.8 months (95% CI 20.3\u201347 months). The median overall survival for the patients who presented with locally advanced, unresectable disease was 15.3 months (95% CI 12\u201319.3 months). The median overall survival for those who presented with metastatic disease was 7.2 months (95% CI 5.2\u20139.5 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the largest reported cohort of young patients with PAC \u226445 years of age. The data suggest that patients with stages I\u2013II disease may have an improved prognosis, however the prognosis for stages III\u2013IV patients appears to be similar to the typical (older) patient population with PAC. J. Surg. Oncol. 2009;100:8\u201312. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.21292","type":"journal-article","created":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T13:16:32Z","timestamp":1240319792000},"page":"8-12","source":"Crossref","is-referenced-by-count":35,"title":["Pancreatic adenocarcinoma in a young patient population\u201412\u2010year experience at Memorial Sloan Kettering Cancer Center"],"prefix":"10.1002","volume":"100","author":[{"given":"A.","family":"Duffy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Capanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kurtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.H.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.S.","family":"Klimstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.M.","family":"O'Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/CA.2007.0010"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1414.024"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.9525"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21040"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-007-0384-8"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9249-8"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.9.1019"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.3.267"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm123"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11860"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.027292"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1385\/IJGC:32:2-3:143"},{"key":"e_1_2_1_14_2","first-page":"545","article-title":"K\u2010ras oncogene activation in adenocarcinoma of the human pancreas. 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