{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:28:19Z","timestamp":1790162899973,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,8,20]],"date-time":"2009-08-20T00:00:00Z","timestamp":1250726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"La Fundaci\u00f3n La Cruz Azul"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cancers of the ampulla are unusual and morphologically heterogeneous. The NCI's SEER Program is now large enough so that unusual cancers can be studied. Based on pathologic and epidemiologic characteristics of cancer of the ampulla available in SEER, important clinicopathological correlations can be made.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients with cancer of the ampulla were identified between 1973 and 2005. Demographic features, distribution of histological types, age\u2010specific incidence rates, and 5\u2010year survival rates according to stage and histologic type were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 5,625 cases of ampullary cancer. Ampullary cancer has been increasing since 1973. In both African Americans and Caucasians, the disease is more common in men. Adenocarcinomas, NOS comprised 65% of all histological types. Survival depends on stage, grade, and histologic type. Papillary carcinomas had a more favorable survival than other types; carcinomas arising in adenomas had a more favorable survival than adenocarcinomas not associated with adenomas. Logarithmic transformation of age\u2010related incidence data demonstrates that cancers having differing histopathologic phenotypes represent a single population of tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prognostic factors include histologic type, grade, stage, and coexisting adenomas. These data should be included in pathology reports. Although certain histologic types exhibit morphologic differences, their pathogenesis appears to be similar. J. Surg. Oncol. 2009;100:598\u2013605. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.21374","type":"journal-article","created":{"date-parts":[[2009,8,20]],"date-time":"2009-08-20T22:12:18Z","timestamp":1250806338000},"page":"598-605","source":"Crossref","is-referenced-by-count":254,"title":["Cancers of the ampulla of vater: Demographics, morphology, and survival based on 5,625 cases from the SEER program"],"prefix":"10.1002","volume":"100","author":[{"given":"Jorge","family":"Albores\u2010Saavedra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold M.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Batich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald E.","family":"Henson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,8,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-170"},{"key":"e_1_2_1_3_2","volume-title":"Atlas of tumor pathology: Tumors of the gallbladder, extrahepatic bile ducts, and ampulla of Vater","author":"Albores\u2010Saavedra J","year":"2000"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198902000-00008"},{"key":"e_1_2_1_5_2","unstructured":"Surveillance Epidemiology and End Results (SEER).SEER*Stat database: Incidence\u2010SEER regs limited\u2010use Nov 2006 sub (1973\u20132005 varying)\u2010linked to county attributes\u2010total U.S. 1969\u20132004 counties. 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