{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:03:56Z","timestamp":1765609436109},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Cholangiocarcinoma can be classified as intrahepatic (ICC) or perihilar (PCC). The objectives of this study is to evaluate the surgical outcomes of patients with PCC and ICC, identify the main prognostic factors related to survival and compare the outcome and the prognostic factors of PCC and ICC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010five out of 152 patients observed between January 1990 and December 2007 at Surgical Division of University of Verona Medical School underwent the resection of ICC (33 patients) or PCC (62 patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall median survival was 24 months with a 3\u2010 and 5\u2010year survival rate of 45% and 23%, respectively. Prognostic factors for survival were macroscopic types of the tumor, the resection of extrahepatic bile duct, radical resection, lymph node metastases, and macro\u2010vascular invasion. Survival was related with the macroscopic type of the tumors with a 5\u2010year survival rate of 26% and 13% for ICC and PCC, respectively. Univariate analysis identified that negative clinico\u2010pathological factors where significant more frequently found in PCC compared to ICC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We identified that ICC have longer survival rate compared to PCC. PCC showed a higher frequency of negative clinico\u2010pathological factors such as non\u2010radical (R+) resection, perineural infiltration and macro\u2010vascular invasion. J. Surg. Oncol. 2010;101:111\u2013115. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.21452","type":"journal-article","created":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T18:25:10Z","timestamp":1259691910000},"page":"111-115","source":"Crossref","is-referenced-by-count":17,"title":["Does intrahepatic cholangiocarcinoma have better prognosis compared to perihilar 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