{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T17:57:58Z","timestamp":1759341478945},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,1,15]],"date-time":"2010-01-15T00:00:00Z","timestamp":1263513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The study aim was to investigate our institutional strategies for axillary staging in breast cancer patients undergoing neoadjuvant therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified 595 patients treated with neoadjuvant therapy between 2000 and 2007. Axillary staging occurred by four methods: (1) pre\u2010therapy fine needle aspiration biopsy (FNAB); (2) pre\u2010therapy sentinel lymph node biopsy (SLNB); (3) post\u2010therapy SLNB; or (4) post\u2010therapy axillary lymph node dissection (ALND).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 595 patients, 115 underwent FNAB (Group 1; 36 N0, 79 N+), 88 underwent SLNB pre\u2010therapy (Group 2; 47 N0, 41 N+), 55 underwent SLNB post\u2010therapy (Group 3; 42 N0, 13 N+), and 337 underwent ALND post\u2010therapy (Group 4; 133 N0, 204 N+). There was no difference between groups according to patient age, race, stage of disease, estrogen\/progesterone receptor and Her\u20102neu status, or type of neoadjuvant therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The lack of standardized recommendations for axillary staging in the setting of neoadjuvant therapy leads to variable approaches within an institution. The use of ALND without pre\u2010therapy axillary assessment may result in over\u2010treatment of patients. Randomized clinical trials are needed to determine the feasibility and accuracy of SLNB following neoadjuvant therapy. Until such data are available, pre\u2010therapy axillary staging may reduce the number of unnecessary lymph node dissections. J. Surg. Oncol. 2010;102:404\u2013407. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.21466","type":"journal-article","created":{"date-parts":[[2010,1,15]],"date-time":"2010-01-15T14:07:24Z","timestamp":1263564444000},"page":"404-407","source":"Crossref","is-referenced-by-count":3,"title":["Axillary staging prior to or after neoadjuvant systemic therapy? A single institutional experience"],"prefix":"10.1002","volume":"102","author":[{"given":"Fatema Al","family":"Mushawah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus C.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Margenthaler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,15]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.7.2483"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji021"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn309"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0136-3"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810013391401"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2006.03.592"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10786"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9403-y"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9759-z"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001201)89:11<2187::AID-CNCR6>3.0.CO;2-#"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.21466","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.21466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T13:29:11Z","timestamp":1696858151000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.21466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,15]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1002\/jso.21466"],"URL":"https:\/\/doi.org\/10.1002\/jso.21466","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,15]]}}}