{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T12:17:08Z","timestamp":1768997828580,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T00:00:00Z","timestamp":1264723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC-95-2314-B-006-056"],"award-info":[{"award-number":["NSC-95-2314-B-006-056"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Distant metastasis resulting from carcinoma cell detachment from the primary tumor involves modification of adhesion molecules. This study was conducted to examine the correlation of E\u2010cadherin\/\u03b2\u2010catenin expression with survival and recurrence in ampullary neoplasms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with diagnoses of ampullary neoplasms were enrolled in the study. Demographics, operative findings, and histopathological data were collected by retrospective chart review. Expression of E\u2010cadherin and \u03b2\u2010catenin were detected by immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 110 patients were enrolled in the study. Preservation of membranous staining of E\u2010cadherin was noted in 41 (37%) patients, aberrant cytoplasmic staining in 48 (44%) patients, and complete loss in 21 (19%) patients. Loss of E\u2010cadherin was associated with pancreatic invasion, recurrence, and poor prognosis. Membranous staining of \u03b2\u2010catenin was noted in 65 (59%) patients, cytoplasmic or nuclear accumulation in 16 (15%) patients, and complete loss in 29 (26%) patients. Loss of \u03b2\u2010catenin expression was associated with tumor markers, ulcerative type, liver metastases, and poor prognosis. Pancreatic invasion, lymph node involvement, and loss of \u03b2\u2010catenin expression were predictors of disease recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Loss of the E\u2010cadherin\/\u03b2\u2010catenin complex is related to poor prognosis in ampullary cancer. Loss of \u03b2\u2010catenin is predictor of recurrence in multivariate analysis. J. Surg. Oncol. 2010; 101:356\u2013362. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.21493","type":"journal-article","created":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T13:52:57Z","timestamp":1264773177000},"page":"356-362","source":"Crossref","is-referenced-by-count":30,"title":["Loss of E\u2010cadherin and \u03b2\u2010catenin is correlated with poor prognosis of ampullary 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