{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:36:46Z","timestamp":1791596206811,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,4,9]],"date-time":"2010-04-09T00:00:00Z","timestamp":1270771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>We evaluated the outcome of pelvic exenteration in women with locally advanced primary or recurrent gynecological malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All pelvic exenteration procedures performed between 01\/2003 and 06\/2009 were evaluated. Extent of surgical radicality, operative techniques, and outcome were evaluated. Kaplan\u2013Meier curves were calculated for Overall (OS) and progression\u2010free survival (PFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010seven patients (median age: 52.5 years) were evaluated. Ten of 47 patients (21.3%) had a primary and 37(78.7%) a relapsed cancer. Most common (80.8%) site of origin was the cervix. Patients (80.8%) had undergone previous pelvic irradiation. A total exenteration was performed in 32\/47 patients (68%). A complete tumor resection was obtained in 23 patients (49%). Thirty\u2010three patients (70.2%) had at least one major complication, including ileus (8.5%), intestinal\u2010fistula (29.8%), ureteral anastomotic insufficiency (6.4%), abscess (6.4%), and cardiothrombotic events (23.4%). At a median follow\u2010up of 7 months (range: 1\u201342), 22\/47 patients (46.8%) died and 22\/47 (46.8%) experienced a relapse. Median OS was 4 months (range: 0.1\u201316) and 22 months (range: 6\u201342) for patients with versus without postoperative tumor residuals, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.0006), while median PFS was 4 months (range:0.1\u201316) versus 12months (range: 6\u201342) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Radical pelvic exenteration due to advanced pelvic malignancies may be associated with a high morbidity. Complete tumor resection is associated with a significantly higher overall and PFS. J. Surg. Oncol. 2010; 101:507\u2013512. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.21518","type":"journal-article","created":{"date-parts":[[2010,4,12]],"date-time":"2010-04-12T17:41:22Z","timestamp":1271094082000},"page":"507-512","source":"Crossref","is-referenced-by-count":67,"title":["Long\u2010term clinical outcome of pelvic exenteration in patients with advanced gynecological malignancies"],"prefix":"10.1002","volume":"101","author":[{"given":"Christina","family":"Fotopoulou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kraetschell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg 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