{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:43:56Z","timestamp":1778539436727,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,4,9]],"date-time":"2010-04-09T00:00:00Z","timestamp":1270771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This work was to evaluate cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for advanced gastric cancer (GC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CRS and HIPEC were performed on 28 GC patients with peritoneal carcinomatosis (PC) and\/or malignant ascites, with survival and perioperative safety as study endpoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 30 CRS and HIPEC procedures were performed. Cytoreduction scores ratings (CCR) were CCR\u20100 in 11 (39.2%), CCR\u20101 in 6 (21.4%), CCR\u20102 in 8 (28.8%), and CCR\u20103 in 3 (10.6%) cases. The 6\u2010, 12\u2010, 18\u2010, and 24\u2010month survival rates were 75%, 50%, 43%, and 43%, respectively. The median survivals of patients with PCI \u226420 and high PCI &gt;20 were 27.7 months (95% CI 15.2\u201340.3 months) and 6.4 months (95% CI 3.8\u20138.9 months) (<jats:italic>P<\/jats:italic>\u2009=\u20090.000). The estimated median survival for patients with CCR\u20100, CCR\u20101, and CCR\u20102 and 3 were 43.4 months (95% CI, 26.9\u201359.9 months), 9.5 months (95% CI 6.4\u201312.6 months), and 7.5 months (95% CI 3.0\u201313.6 months) (<jats:italic>P<\/jats:italic>\u2009=\u20090.001, CCR0 vs. CCR1\u20103). No perioperative death but 1 (3.6%) serious adverse event occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CRS plus HIPEC could offer survival advantage for selected GC patients with PC and\/or ascites, with acceptable safety profile. J. Surg. Oncol. 2010; 101:457\u2013464. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.21519","type":"journal-article","created":{"date-parts":[[2010,4,12]],"date-time":"2010-04-12T17:41:01Z","timestamp":1271094061000},"page":"457-464","source":"Crossref","is-referenced-by-count":74,"title":["Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy to treat gastric cancer with ascites and\/or peritoneal carcinomatosis: Results from a Chinese center"],"prefix":"10.1002","volume":"101","author":[{"given":"Xiao\u2010Jun","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Yonemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,4,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24290"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"e_1_2_1_4_2","first-page":"246","article-title":"Analysis on epidemic characteristics of cancer death rate in China","volume":"25","author":"Zhang WD","year":"2009","journal-title":"Chinese J Health Educ"},{"key":"e_1_2_1_5_2","first-page":"991","article-title":"Evaluation of tumor markers biochip C12 system in the diagnosis of gastric cancer and the strategies for improvement: Analysis of 100 cases","volume":"55","author":"Chen C","year":"2008","journal-title":"Hepato\u2010Gastroenterology"},{"key":"e_1_2_1_6_2","first-page":"1750","article-title":"Carcinoembryonic antigen level is related to tumor invasion into the serosa of the stomach: Study on 166 cases and suggestion for new therapy","volume":"56","author":"Zhang YH","year":"2009","journal-title":"Hepato\u2010Gastroenterology"},{"key":"e_1_2_1_7_2","first-page":"1109","article-title":"Long\u2010term results of surgical treatment of stomach cancer: Clinical experience of forty years from Sun Yat\u2010sen University Cancer Center","volume":"43","author":"Zhan YQ","year":"2005","journal-title":"Chin J Surg"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-001-0632-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.05.123"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.4321\/S1130-01082005001000005"},{"key":"e_1_2_1_11_2","first-page":"357","article-title":"Cytoreduction and intraperitoneal chemotherapy for carcinomatosis from gastric cancer","volume":"134","author":"Yonemura Y","year":"2007","journal-title":"Cancer Treat Res"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000115)88:2<358::AID-CNCR16>3.0.CO;2-O"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890115)63:2<364::AID-CNCR2820630228>3.0.CO;2-V"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830101)51:1<136::AID-CNCR2820510127>3.0.CO;2-X"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4164"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ssu.10042"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9487-4"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800830605"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2004.01.035"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0226-2"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00011681"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002800051093"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(03)00035-8"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4695"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2005.12.001"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2000.1038"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.1.26"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000012086"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9479-4"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072252"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-002-6344-2"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-002-6279-7"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01358.x"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-7404(92)90034-I"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.SLA.0000072260.77776.39"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198807000-00005"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(96)80145-0"},{"key":"e_1_2_1_38_2","first-page":"1776","article-title":"Intraoperative chemohyperthermic peritoneal perfusion as an adjuvant to gastric cancer: Final results of a randomized controlled study","volume":"48","author":"Yonemura Y","year":"2001","journal-title":"Hepato\u2010Gastroenterolgy"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2007.12.003"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990201)85:3<529::AID-CNCR3>3.0.CO;2-9"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2003.12.014"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900101)65:1<65::AID-CNCR2820650115>3.0.CO;2-L"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940415)73:8<2048::AID-CNCR2820730806>3.0.CO;2-Q"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.139.1.20"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s101200100013"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-999-0790-0"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921215)70:12<2754::AID-CNCR2820701205>3.0.CO;2-A"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21052"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.21519","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.21519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T16:06:52Z","timestamp":1700669212000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.21519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,9]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1002\/jso.21519"],"URL":"https:\/\/doi.org\/10.1002\/jso.21519","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,9]]}}}