{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T18:35:36Z","timestamp":1767033336594},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,5,24]],"date-time":"2010-05-24T00:00:00Z","timestamp":1274659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The management of patients with peri\u2010ampullary liver metastasis remains controversial. We sought to assess the safety and efficacy of curative intent surgery for peri\u2010ampullary liver metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 1993 and 2009, 40 patients underwent curative intent surgery (resection and\/or radiofrequency ablation (RFA)) for peri\u2010ampullary liver metastasis. Clinicopathologic and outcome data were collected and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Location of the primary tumor was pancreas head (n\u2009=\u200920), ampulla of Vater (n\u2009=\u200910), distal bile duct (n\u2009=\u20095), or duodenum (n\u2009=\u20095). Most patients (n\u2009=\u200927) presented with synchronous disease, while 13 patients presented with metachronous disease following a median disease\u2010free interval of 22 months. Most patients (n\u2009=\u200925) presented with hepatic metastasis from pancreaticobiliary origin (pancreatic or distal common bile duct) compared with 15 patients who had metastasis from an intestinal\u2010type primary (ampullary or duodenal). There were no differences in metastatic tumor number or size between these groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Post\u2010operative morbidity and mortality was 30% and 5% respectively. Overall 1\u2010 and 3\u2010year survival was 55% and 18%. Patients who underwent resection of liver metastasis from intestinal\u2010type tumors experienced a longer survival compared with patients who had pancreaticobiliary lesions (median: 13 months vs. 23 months; <jats:italic>P<\/jats:italic>\u2009=\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Curative intent surgery for peri\u2010ampullary liver metastasis was associated with post\u2010operative morbidity and a 5% mortality rate. Although the overall survival benefit was modest, patients with liver metastasis from intestinal\u2010type tumors experienced improved survival following resection of liver metastasis compared with pancreaticobiliary lesions. J. Surg. Oncol. 2010;102:256\u2013263. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.21610","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T01:08:19Z","timestamp":1274922499000},"page":"256-263","source":"Crossref","is-referenced-by-count":51,"title":["Safety and efficacy of curative intent surgery for peri\u2010ampullary liver metastasis"],"prefix":"10.1002","volume":"102","author":[{"given":"Mechteld C.","family":"de Jong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L.","family":"Wolfgang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzo","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark G.","family":"van Vledder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Eckhauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph M.","family":"Herman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barish H.","family":"Edil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Choti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard D.","family":"Schulick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy M.","family":"Pawlik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,5,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199806000-00005"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-170"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(99)00049-6"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199709000-00004"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200206000-00002"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b4539b"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199909000-00004"},{"key":"e_1_2_5_9_2","first-page":"19","article-title":"Results following surgical resection for malignant pancreatic neuroendocrine tumours. 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