{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T07:02:44Z","timestamp":1724482964899},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,6,11]],"date-time":"2010-06-11T00:00:00Z","timestamp":1276214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>A failure to visualize axillary sentinel nodes in lymphoscintigraphy may lead to an unsuccessful sentinel node biopsy (SNB) and subsequent axillary lymph node dissection (ALND). To avoid unnecessary ALND, a second radioisotope injection may be given but has been considered hazardous. We investigated the axillary recurrence rate after tumor\u2010negative SNB in breast cancer patients who received a second tracer injection after axillary visualization failure in lymphoscintigraphy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Altogether 1,309 breast cancer patients who underwent a tumor\u2010negative SNB without an ALND were included. Two hundred seven (15.8%) patients received a second tracer injection due to visualization failure in lymphoscintigraphy and 1,102 (84.2%) did not. All patients received a blue dye injection prior to the SNB. The median follow\u2010up time was 43 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No isolated cancer recurrences were diagnosed in the ipsilateral axilla among patients who received two radioisotope injections. Disease\u2010free survival and overall survival were similar among patients with one or two radioisotope injections (<jats:italic>P<\/jats:italic>\u2009=\u20090.122 and <jats:italic>P<\/jats:italic>\u2009=\u20090.200, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Additional radiocolloid tracer injection after axillary non\u2010visualization in lymphoscintigraphy is safe and does not increase axillary recurrence risk after tumor\u2010negative SNB. The results suggest that such patients can be safely managed with SNB without a need to perform an ALND. J. Surg. Oncol. 2010;102:649\u2013655. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.21637","type":"journal-article","created":{"date-parts":[[2010,6,11]],"date-time":"2010-06-11T16:55:53Z","timestamp":1276275353000},"page":"649-655","source":"Crossref","is-referenced-by-count":5,"title":["Safety of sentinel node biopsy in breast cancer patients who receive a second radioisotope injection after visualization failure in lymphoscintigraphy"],"prefix":"10.1002","volume":"102","author":[{"given":"Tuomo J.","family":"Meretoja","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Joensuu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4ivi S.","family":"Heikkil\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjut H.","family":"Leidenius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,10,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012782"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02574481"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2006.05.013"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199509000-00016"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.01.064"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0403-y"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-004-1681-z"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4741.2002.08203.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2003.08.005"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.05.008"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2005.09.001"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5763"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200101000-00009"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(98)00011-8"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1075-122X.2005.21591.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4741.2002.08402.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.02.012"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32831369cb"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841850600830654"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-1931-8"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2007.03.028"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2003.09.014"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0397-5"},{"key":"e_1_2_6_25_2","volume-title":"World Health Organization Classification of Tumours. 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