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Genetic polymorphism has been reported as a factor for increased susceptibility of HCC. Glutathione\u2010<jats:italic>S<\/jats:italic>\u2010transferases theta (GSTT1) and mu (GSTM1) play essential roles in detoxification of ingested xenobiotics and modulation of the susceptibility of gene\u2010related cancer. The aim of this study was to estimate the relationships between these two gene polymorphisms and HCC risk and clinicopathological status in Taiwanese.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Polymerase chain reaction (PCR) was used to determine gene polymorphisms of 102 patients with HCC and 386 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both gene polymorphisms were not associated with the clinical pathological status of HCC and serum levels of liver\u2010related clinical pathological markers. While no relationship between GSTM1 gene polymorphism and HCC susceptibility was found, individuals of age <jats:styled-content>&lt;<\/jats:styled-content>56 years old with GSTT1 present genotype have a risk of 2.77\u2010fold (95% CI: 1.09\u20137.09) for HCC compared to that with null variant, after adjustment for other confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>GSTT1 and GSTM1 null genotypes do not associate with increased risk of HCC. J. Surg. Oncol. 2010;102:301\u2013307. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.21643","type":"journal-article","created":{"date-parts":[[2010,7,29]],"date-time":"2010-07-29T13:19:12Z","timestamp":1280409552000},"page":"301-307","source":"Crossref","is-referenced-by-count":6,"title":["Influence of glutathione\u2010<i>S<\/i>\u2010transferase theta (GSTT1) and mu (GSTM1) gene polymorphisms on the susceptibility of hepatocellular carcinoma in 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