{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:17:49Z","timestamp":1785842269106,"version":"3.56.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,8,23]],"date-time":"2010-08-23T00:00:00Z","timestamp":1282521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>In contrast to primary ovarian cancer, the value of surgery in relapsed\u2010OC (ROC) remains unclear. We evaluated surgical and clinical outcome of secondary cytoreduction in ROC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All consecutive ROC patients who underwent secondary tumor\u2010debulking surgery were systematically analyzed as based on a validated intraoperative documentation tool. Tumor dissemination pattern, operative and clinical outcome were evaluated. Cox\u2010regression analysis was performed to identify independent predictors of mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 09\/2000 and 10\/2008, 240 operations were evaluated; 184 patients (81.1%) were platinum\u2010sensitive and 43 (20%) platinum\u2010resistant. 47.5% of the patients had ascites, while 85.8% presented a multifocal tumor dissemination pattern. In 53.8% a complete tumor resection was achieved; in another 24.2%, postoperative tumor residuals were &lt;1\u2009cm. In multivariate analysis, no tumor resection (HR: 7.6; 95% CI: 2.9\u201319.9), ascites &gt;500\u2009ml (HR: 6.76; 95% CI: 3.77\u201312.1), platinum resistance (HR: 3.1; 95% CI: 1.26\u20137.7), and initial FIGO stage IV (HR: 2.86; 95% CI: 1.16\u20137) were the most significant risk factors for mortality. Median OS was 42.3 months (95% CI: 24.37\u201360.2); 17.7 months (95% CI: 12.27\u201323.13); and 7.7 months (95% CI: 3.1\u201312.3) for patients with complete tumor resection, tumor residuals \u22641 and &gt;1\u2009cm, respectively (trend <jats:italic>P<\/jats:italic>\u2010value &lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Absence of ascites, platinum\u2010sensitivity, initial FIGO stage &lt;IV, and complete tumor resection correlate with a significantly better long\u2010term prognosis after ROC surgery. However, a significant trend of continuously improving survival associated with increasing tumor reduction rates could be identified even in patients where a complete tumor resection is not achievable. J. Surg. Oncol. 2010;102:656\u2013662. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.21652","type":"journal-article","created":{"date-parts":[[2010,8,29]],"date-time":"2010-08-29T06:17:23Z","timestamp":1283062643000},"page":"656-662","source":"Crossref","is-referenced-by-count":62,"title":["Role of secondary cytoreductive surgery in ovarian cancer relapse: Who will benefit? A systematic analysis of 240 consecutive patients"],"prefix":"10.1002","volume":"102","author":[{"given":"Jalid","family":"Sehouli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Ioana","family":"Braicu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai J.","family":"B\u00fchling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Bahra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Neuhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Lichtenegger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Fotopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.08.034"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9098(200009)75:1<24::AID-JSO5>3.0.CO;2-L"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20106"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21845"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2009.20.2.101"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9058-0"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0357-0"},{"key":"e_1_2_5_9_2","first-page":"263","article-title":"Changing in definitions of clinical staging for carcinoma of the cervix and ovary","volume":"156","author":"International Federation of Gynecology and Obstetrics","year":"1987","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21288"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-41864"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.11.005"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1586\/era.09.49"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19951101)76:9<1606::AID-CNCR2820760917>3.0.CO;2-H"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22447"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602466"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2005.00430.x"},{"key":"e_1_2_5_18_2","unstructured":"HarterP SehouliJ ReussA et al.:Predictive factors for resection in recurrent ovarian cancer (ROC). Intergroup study of AGO KOMMISSION OVAR AGO\u2010OVAR AGO AUSTRIA MITO AND NOGGO. 12th Biennial Meeting International Gynecologic Cancer Society; October 25\u201328 2008; Bangkok 2008 [abstract 38]."},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5992"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921015)70:8<2129::AID-CNCR2820700820>3.0.CO;2-U"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.08.033"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9273-8"},{"key":"e_1_2_5_23_2","article-title":"Role of computed tomography in the surgical management of patients with bowel obstruction secondary to recurrent ovarian carcinoma","author":"Alejandro Rauh\u2010Hain J","journal-title":"Ann Surg Oncol"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.04.006"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.21652","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.21652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T19:58:35Z","timestamp":1696795115000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.21652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,23]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1002\/jso.21652"],"URL":"https:\/\/doi.org\/10.1002\/jso.21652","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,23]]}}}