{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:13:25Z","timestamp":1761988405548},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T00:00:00Z","timestamp":1310083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Portal clamping during liver resection decreases intraoperative blood loss, but causes ischemic\u2010reperfusion (I\u2010R) injury. Intermittent portal clamping (IPC) and ischemic preconditioning (IP) decreased I\u2010R injury in animal models. Most of the human studies about IP excluded cirrhotic patients, whose liver is more vulnerable to I\u2010R injury. The effect of IP and IPC during extended liver resection was investigated in this randomized controlled trial, with special respect to cirrhotic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred sixty patients (100 normal liver, 60 cirrhotic) undergoing major liver resection were randomized to receive IPC (15\u2009min ischemia, 5\u2009min reperfusion), or IP (10\u2009min ischemia, 10\u2009min reperfusion). Serum oxygen\u2010derived free radicals (ODFR) and antioxidant concentrations (preoperative, after reperfusion and 7th postoperative day), such as \u201cconventional\u201d liver tests (preoperative, 1st, 3rd, and 7th postoperative day) were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IP resulted in significantly lower peak ODFR, AST, ALT, and bilirubin levels after liver resection than IPC (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The level of serum antioxidants after reperfusion was significantly higher in IP than in IPC groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In cirrhotic patients without IP none of these values normalized until the 7th postoperative day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ischemic preconditioning\u2014especially in patients with liver cirrhosis\u2014is a suitable method to decrease the I\u2010R injury of the liver. J. Surg. Oncol. 2011; 104:647\u2013653. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.21907","type":"journal-article","created":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T10:08:10Z","timestamp":1310638090000},"page":"647-653","source":"Crossref","is-referenced-by-count":15,"title":["The effect of ischemic preconditioning on redox status during liver resections\u2014randomized controlled trial"],"prefix":"10.1002","volume":"104","author":[{"given":"Oszk\u00e1r","family":"Hahn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Bl\u00e1zovics","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"V\u00e1li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter 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