{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:51:06Z","timestamp":1788871866891,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T00:00:00Z","timestamp":1300924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chung Shan Medical University and Changhua Christian Hospital","award":["98-CCH-CSMU-08"],"award-info":[{"award-number":["98-CCH-CSMU-08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Because matrix metalloproteinase\u20102 (MMP\u20102) is associated with tumor progression and tissue inhibitor of MMP\u20102 (TIMP\u20102) selectively inhibits MMP\u20102, we investigate the implication of TIMP\u20102 in carcinogenesis of uterine cervix.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010six cervical cancer tissues and their normal counterparts were collected to evaluate semi\u2010quantitative mRNA expression of TIMP\u20102. Eighty\u2010two cervical cancer, 26 high\u2010grade and 26 low\u2010grade dysplasia, and 26 normal tissues were collected to construct tissue microarrays for immunohistochemical study. We evaluated TIMP\u20102 immunoreactivity using H scores in cervical carcinogenesis. Semi\u2010quantitative expression of MMP\u20102 was also detected for comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cervical cancer tissues exhibited statistically lower semi\u2010quantitative TIMP\u20102 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.028) or higher MMP\u20102 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.036) mRNA expression than their normal counterparts. None of cervical cancer tissues exerted elevated TIMP\u20102 and reduced MMP\u20102 mRNA expression simultaneously. Cancer tissues have significantly lower TIMP\u20102 or higher MMP\u20102 H scores than high\u2010grade and low\u2010grade dysplasia or normal tissues of uterine cervix.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low expression of TIMP\u20102 or high expression of MMP\u20102 is semi\u2010quantitatively demonstrated in cancer of uterine cervix. TIMP\u20102 is implicated in cervical carcinogenesis. J. Surg. Oncol. 2011;104:210\u2013215. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.21918","type":"journal-article","created":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T12:26:12Z","timestamp":1300969572000},"page":"210-215","source":"Crossref","is-referenced-by-count":0,"title":["Semi\u2010quantitative expression of tissue inhibitor of matrix metalloproteinase\u20102 in cancer of uterine 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