{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:25:47Z","timestamp":1782390347997,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T00:00:00Z","timestamp":1310083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the role of intra\u2010lesional interleukin\u20102 (IL\u20102) injection for treatment of in\u2010transit melanoma metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with in\u2010transit metastases were treated with intra\u2010lesional IL\u20102 injections. Two independent observers evaluated response to treatment using the Response Evaluation Criteria in Solid Tumors (RECIST) criteria. A blinded pathologist confirmed clinical response with post\u2010treatment biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010nine patients were included. Patients received biweekly IL\u20102 injections. At each treatment session, a mean of 2.08\u2009ml (5\u2009\u00b5\/ml) of IL\u20102 were distributed amongst a mean of 12 (range 1\u201357) in\u2010transit lesions. Patients were followed for an average of 30.4 months (range 2.2\u201366.6 months).<\/jats:p><jats:p>The overall patient response rate was 82%. A complete response was obtained in 20 patients (51%), a partial response in 12 (31%), and no response in seven (18%). Of the 629 in\u2010transit metastases, 479 (76%) completely resolved. Complete responders had a significant in transit\u2010free (<jats:italic>P<\/jats:italic>\u2009=\u20090.0005) and an overall (<jats:italic>P<\/jats:italic>\u2009=\u20090.012) survival advantage compared with partial responders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The treatment of in\u2010transit metastatic melanoma with intra\u2010lesional IL\u20102 resulted in a 76% percent clearance of lesions. Complete response is associated with superior in transit\u2010free and overall survival when compared with partial response. J. Surg. 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