{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:27:41Z","timestamp":1740104861099,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,7,2]],"date-time":"2011-07-02T00:00:00Z","timestamp":1309564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30600710","81070841","91029712"],"award-info":[{"award-number":["30600710","81070841","91029712"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>All trans retinoic acid (ATRA) is used as standard of care in promyelocytic leukemia. Not much is known about the gene expression profile in ATRA\u2010treated tongue cancer cells. We performed a genome\u2010wide transcriptional profiling of ATRA\u2010treated tongue cancer cells to understand the pathways that mediate ATRA action in tongue cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured the effects of ATRA on the proliferation of SCC\u20109 human tongue carcinoma cells. The differential gene expression profile was measured by microarray analysis of untreated and ATRA\u2010treated cells and expression of key genes was validated by real\u2010time RT\u2010PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ATRA treatment (24 and 48\u2009hr) significantly inhibited SCC\u20109 cell proliferation in a dose\u2010dependent manner. SCC\u20109 cells treated for 48\u2009hr with ATRA showed upregulation of 276 genes, including ANGPTL4, GDF15, ICAM1 and TUSC4, and downregulation of 43 genes, including CXCL10. Validation by real\u2010time PCR showed a significant upregulation of intracellular adhesion molecule 1 (ICAM1) and downregulation of CXCL10 and IL32.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ATRA had an anti\u2010tumor effect in tongue cancer cells. This effect is likely mediated via upregulation of ICAM1 and downregulation of CXCL10 and IL32. J. Surg. Oncol. 2011; 104:830\u2013835. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.21998","type":"journal-article","created":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T12:01:36Z","timestamp":1309780896000},"page":"830-835","source":"Crossref","is-referenced-by-count":0,"title":["Genome\u2010wide transcriptional profiling analysis of all trans retinoic acid\u2010treated tongue carcinoma SCC\u20109 cells"],"prefix":"10.1002","volume":"104","author":[{"given":"Yaohui","family":"Dai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2003.10.009"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/412908"},{"key":"e_1_2_6_4_2","first-page":"3055","article-title":"Frequent novel DNA copy number increase in squamous cell head and neck tumors","volume":"55","author":"Brzoska PM","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_6_5_2","first-page":"4506","article-title":"Molecular cytogenetic characterization of head and neck squamous cell carcinoma and refinement of 3q amplification","volume":"61","author":"Singh B","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199803)20:2<145::AID-HED8>3.0.CO;2-2"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205351"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.9.8801176"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2010.521507"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203088"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-159"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.05.007"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10051"},{"key":"e_1_2_6_14_2","first-page":"2","article-title":"A pilot phase II trial of all\u2010trans retinoic acid (Vesanoid) and paclitaxel (Taxol) in patients with recurrent or metastatic breast cancer","author":"Bryan M","year":"2010","journal-title":"Invest New Drugs"},{"key":"e_1_2_6_15_2","first-page":"935","article-title":"Receptor\u2010related mechanism of proliferation inhibilion and apoptosis induetion of human tongue squamous cell line Tca8113 by retinoids","volume":"25","author":"Niu XW","year":"2005","journal-title":"Di Yi Jun Yi Da Xue Xue Bao"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1534"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10875"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(02)00108-2"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/73432"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-11"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2001.tb01046.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02828205"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200522758"},{"key":"e_1_2_6_24_2","first-page":"141","article-title":"IL\u201032: A newly\u2010discovered proinflammatory cytokine","volume":"23","author":"Felaco P","year":"2009","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200903-0400OC"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-28-139"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00318-5"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.10.088"},{"key":"e_1_2_6_29_2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/ijc.25356","article-title":"CADM1\/TSLC1 inactivation by promoter hypermethylation is a frequent event in colorectal carcinogenesis and correlates with late stages of the disease","volume":"128","author":"Chen K","journal-title":"Int J Cancer;"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/13547500903261362"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mol.0000217896.67444.05"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.100129"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.108175"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2010.078600"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1862"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280319"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0663"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-27-37"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050575"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.6452"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.21998","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.21998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.21998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T12:49:49Z","timestamp":1697633389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.21998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,2]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1002\/jso.21998"],"URL":"https:\/\/doi.org\/10.1002\/jso.21998","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"type":"print","value":"0022-4790"},{"type":"electronic","value":"1096-9098"}],"subject":[],"published":{"date-parts":[[2011,7,2]]}}}