{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:12:24Z","timestamp":1788873144478,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,9,12]],"date-time":"2011-09-12T00:00:00Z","timestamp":1315785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2012,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Apocrine adenocarcinoma is a rare neoplasm. There is a paucity of data on demographics and survival with no clear consensus on management of at risk lymph nodes, therefore, we analyzed a large cohort of patients identified via a national tumor registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients ages 17\u201391 from 1973 to 2006 were identified in the SEER registry and excluded breast and non\u2010cutaneous neoplasms. Data analyzed included basic demographics, survival, surgical therapy, and stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 186 patients with apocrine adenocarcinoma were identified. The median age was 67 years, 76% were white and there was an equal distribution of males and females. The most common site was trunk (53%) followed by head and neck (35%). Surgery was performed on most patients (96%), either excision (50%) or wide excision (30%). Lymph node metastases were present in 69% patients undergoing node surgery. Median overall survival was 51.5 months. Positive lymph node status (<jats:italic>P<\/jats:italic>\u2009=\u20090.006) and metastatic disease (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were associated with diminished overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cutaneous apocrine adenocarcinoma is a rare neoplasm. Excision is standard treatment. The most important predictor of survival in localized disease is lymph node status; therefore, sentinel lymph node biopsy could be considered in management of this disease. J. Surg. Oncol. 2012;105:415\u2013419. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.22023","type":"journal-article","created":{"date-parts":[[2011,9,12]],"date-time":"2011-09-12T17:12:24Z","timestamp":1315847544000},"page":"415-419","source":"Crossref","is-referenced-by-count":89,"title":["Cutaneous apocrine adenocarcinoma: Defining epidemiology, outcomes, and optimal therapy for a rare neoplasm"],"prefix":"10.1002","volume":"105","author":[{"given":"Kerry L.","family":"Hollowell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Agle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel E.","family":"Zervos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181590ba4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-199904000-00005"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20889"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.019794"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1177\/000313480407000115","article-title":"Sweat gland carcinoma","volume":"70","author":"Brichhov I","year":"2004","journal-title":"Am surg"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197102000-00014"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.032"},{"key":"e_1_2_6_9_2","first-page":"83","article-title":"Carcinoma of sweat glands","volume":"22","author":"Cooper PH","year":"1987","journal-title":"Pathol Annu"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1978.01640140016004"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000018285"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-1-13"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.021394"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc0694"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00804.x"},{"key":"e_1_2_6_16_2","first-page":"73307","article-title":"Infiltrating apocrine adenocarcinoma with extramammary pagetoid spread","author":"Hernandez J","year":"2007","journal-title":"Am Surg"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1757-1626-1-88"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.9923"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03175.x"},{"key":"e_1_2_6_20_2","unstructured":"GreicoEM CassidyRC:Overview of race and hispanic Origin Census 200. 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