{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:11:38Z","timestamp":1788199898155,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T00:00:00Z","timestamp":1310601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2012,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study was to determine whether iron\u2010deficiency anemia (IDA) predicts long\u2010term oncologic outcomes in patients with TNM stage II colon cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and follow\u2010up data were extracted from a prospective colon cancer database. Univariate and multivariate analyses were performed to identify IDA and other predictors of long\u2010term oncologic outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 644 patients, 147 (22.8%) patients presented with IDA. The data were stratified by T3N0M0 and T4N0M0. The distribution difference of IDA between the two subsets was not significant (<jats:italic>P<\/jats:italic>\u2009=\u20090.340). But in the T4N0M0 subset, the incidence of IDA increased with the depth of tumor penetration (75.9% and 18.2% for the patients with and without adjacent organ involvement, respectively, <jats:italic>P<\/jats:italic>\u2009=\u20090.011). IDA predicted a worse disease\u2010free survival among patients with T3N0M0 cancer (472 patients; log\u2010rank test, <jats:italic>P<\/jats:italic>\u2009=\u20090.016; Cox regression, <jats:italic>P<\/jats:italic>\u2009=\u20090.009), but it was not a predictor in T4N0M0 cancer patients (172 patients; log\u2010rank test, <jats:italic>P<\/jats:italic>\u2009=\u20090.016; Cox regression, <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IDA was an independent predictor of long\u2010term outcome in T3N0M0 stage, but not in T4N0M0 colon cancer. T3N0M0 stage colon cancer patients with IDA could be included in future trials of adjuvant therapies. J. Surg. Oncol. 2012;105:371\u2013375. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.22032","type":"journal-article","created":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T12:52:39Z","timestamp":1310647959000},"page":"371-375","source":"Crossref","is-referenced-by-count":27,"title":["Iron\u2010deficiency anemia: A predictor of diminished disease\u2010free survival of T3N0M0 stage colon cancer"],"prefix":"10.1002","volume":"105","author":[{"given":"Li","family":"Zhen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun","family":"Zhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Zhenning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhifeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lv","family":"Zhidong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xiaoxia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jianguang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Huimian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,14]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi098"},{"key":"e_1_2_5_3_2","unstructured":"NCCN:http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/colon.pdf."},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7232-8"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603439"},{"key":"e_1_2_5_6_2","volume-title":"TNM classification of malignant tumours","author":"Sobin LH","year":"2009"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6189.515"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181816083"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800801037"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604165"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/23.2.102"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01454.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.1998.0622"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1622.2000.01916.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/000313480206800614"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050424"},{"key":"e_1_2_5_17_2","first-page":"691","article-title":"Carcinoembryonic antigen (CEA) as an independent prognostic factor in colorectal carcinoma","volume":"132","author":"Bannura G","year":"2004","journal-title":"Rev Med Chil"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198312000-00013"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800730829"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2007.01302.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-010-0904-y"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.22032","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.22032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.22032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T17:28:56Z","timestamp":1700587736000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.22032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,14]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,3,15]]}},"alternative-id":["10.1002\/jso.22032"],"URL":"https:\/\/doi.org\/10.1002\/jso.22032","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,14]]}}}