{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T11:06:30Z","timestamp":1755601590806},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,8,12]],"date-time":"2011-08-12T00:00:00Z","timestamp":1313107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It has been shown that part of the lymph fluid from the right\/dorsal side of the esophagus drains directly into the thoracic duct, whereas the lymph fluid from the left\/ventral side has to pass through lymph nodes before entering the duct. We hypothesized that patients with right\/dorsal tumors have a poorer prognosis than those with left\/ventral tumors because cancer cells from the right\/dorsal quadrant may easily enter the systemic circulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 77 patients with pT1b\u2010 or pT2\u2010staged cancers treated by esophagectomy without neoadjuvant treatment were enrolled in this study. Tumor laterality was determined endoscopically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The tumor location was right\/dorsal in 45 patients and left\/ventral in 32. The right\/dorsal group had a lower lymph node stage (pN, <jats:italic>P<\/jats:italic>\u2009=\u20090.043) and shorter disease\u2010free survival (<jats:italic>P<\/jats:italic>\u2009=\u20090.027). Multivariate analysis demonstrated that tumor laterality [hazard ratio (HR): 0.052, 95% confidence interval (CI): 0.007\u20130.37, <jats:italic>P<\/jats:italic>\u2009=\u20090.003], pN (HR: 3.8, 95% CI: 1.7\u20139.1, <jats:italic>P<\/jats:italic>\u2009=\u20090.001), and tumor size (HR: 1.02, 95% CI: 1\u20131.04, <jats:italic>P<\/jats:italic>\u2009=\u20090.02) were independent prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study to demonstrate a relationship between tumor laterality and prognosis in patients with esophageal squamous cell carcinoma. These findings need to be validated in a prospective large study. J. Surg. Oncol. 2012; 105:66\u201370. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.22069","type":"journal-article","created":{"date-parts":[[2011,8,12]],"date-time":"2011-08-12T13:17:41Z","timestamp":1313155061000},"page":"66-70","source":"Crossref","is-referenced-by-count":4,"title":["The prognostic significance of tumor laterality in patients with esophageal squamous cell carcinoma"],"prefix":"10.1002","volume":"105","author":[{"given":"Shinji","family":"Mine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Grabsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Sano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyoshi","family":"Ishiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Hirasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Hiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,12]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyp106"},{"key":"e_1_2_7_3_2","unstructured":"Cancer Information Service National Cancer Center. 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