{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:29:20Z","timestamp":1778938160730,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,10,10]],"date-time":"2011-10-10T00:00:00Z","timestamp":1318204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2012,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The prevention of lymphoceles was tested using collagen patch coated with the human coagulation factors (TachoSil) on 58 consecutive patients with endometrial cancer who had undergone hysterectomy and pelvic lymphadenectomy (PL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were randomized in two groups: standard technique plus TachoSil (30 patients, group 1) and standard technique only (28, group 2). All surgical parameters were collected and patients underwent ultrasound examination on postoperative days 7, 14, and 28. The main outcome measures were: the development of symptomatic or asymptomatic lymphoceles, the need for further surgical intervention, as adverse effect of surgery and the drainage volume and duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Same number of lymph nodes in both groups was removed; group 1 showed a lower drainage volume. Lymphoceles developed in 7 patients in group 1 and 16 in group 2, but only 3 were symptomatic in group 1 and 9 symptomatic in group 2, with statistical difference. Percutaneous drainage proved necessary in five cases: only one was in group 1 and four in group 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intraoperative application of TachoSil reduced rate of postoperative lymphocysts after PL, and it seems to provide a useful additional treatment option for reducing drainage volume and preventing lymphocele development after PL. J. Surg. Oncol. 2012; 105:835\u2013840. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.22110","type":"journal-article","created":{"date-parts":[[2011,10,10]],"date-time":"2011-10-10T17:26:00Z","timestamp":1318267560000},"page":"835-840","source":"Crossref","is-referenced-by-count":23,"title":["Prevention of lymphocele in female pelvic lymphadenectomy by a collagen patch coated with the human coagulation factors: A pilot study"],"prefix":"10.1002","volume":"105","author":[{"given":"Andrea","family":"Tinelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Giorda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Manca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Pellegrino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Prudenzano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Guido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Dell'edera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Malvasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016340802160079"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/138955710793564098"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2009.11.002"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp120"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901015)60:8 <2035::AID-CNCR2820601515>3.0.CO;2-8"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016340903418785"},{"key":"e_1_2_7_8_2","first-page":"451","article-title":"Long term complications after radical hysterectomy with pelvic lymphadenectomy","volume":"92","author":"Manchana T","year":"2009","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.212.2.r99au12390"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5345"},{"key":"e_1_2_7_11_2","first-page":"268","article-title":"Pelvic lymphocele following radical para\u2010aortic and pelvic lymphadenectomy for cervical carcinoma: Incidence rate and percutaneous management","volume":"76","author":"Conte M","year":"1990","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_12_2","first-page":"178","article-title":"Clinical and experimental studies on the so\u2010called lymphocyst which develops after radical hysterectomy in cancer of the uterine cervix","volume":"2","author":"Mori N","year":"1955","journal-title":"J Jpn Obstet Gynecol Soc"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(88)90232-6"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5624"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70169-9"},{"key":"e_1_2_7_16_2","volume-title":"Cancer of the cervix: Diagnosis and treatment in current reviews in obstetrics and gynecology, vol. 5","author":"Shingleton HM","year":"1993"},{"key":"e_1_2_7_17_2","first-page":"57","article-title":"Prevention of fistulas and lymphocysts in radical hysterectomy. 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