{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:59:46Z","timestamp":1791136786049,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T00:00:00Z","timestamp":1324339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>A review of all resections for recurrent or metastatic ACC was performed to identify patients who might benefit from a surgical approach, and to identify factors that might aid in prognosis among patients with metastatic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary Background Data<\/jats:title><jats:p>Adrenocortical carcinoma (ACC) is a rare tumor, with frequent recurrences and metastases even after complete resection. Chemotherapy has limited efficacy, and surgical resection of metastatic ACC remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review was performed of all patients who underwent surgical intervention for metastatic ACC in a single tertiary center from 1977 to 2009. All available clinicopathologic data were analyzed to determine potential factors associated with response to treatment and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010seven patients underwent 116 procedures for recurrent or metastatic disease. Twenty\u2010three resections were for liver metastases, 48 for pulmonary metastases, 22 for abdominal disease including local recurrences, and 13 were for metastases at other sites. Median and 5\u2010year survivals from time of first metastasectomy were 2.5 years, and 41%, respectively. The median survival of patients with DFI &lt;12 months was 1.7 years, compared to 6.6 years for patients with DFI &gt;12 months (<jats:italic>P<\/jats:italic>\u2009=\u20090.015). Median survival for right versus left\u2010sided primaries was 1.9 years versus 3.8 years (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). Liver metastases were more common with right\u2010sided primaries (67% vs. 41%, <jats:italic>P<\/jats:italic>\u2009=\u20090.05). Chemotherapy had no impact on survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Resection of recurrent or metastatic ACC is safe, and may result in prolongation of survival in selected patients with DFI greater than 1 year. J. Surg. Oncol. 2012; 105:709\u2013713. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23015","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T15:18:18Z","timestamp":1324394298000},"page":"709-713","source":"Crossref","is-referenced-by-count":89,"title":["Operative management for recurrent and metastatic adrenocortical carcinoma"],"prefix":"10.1002","volume":"105","author":[{"given":"Nicole M.","family":"Datrice","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell C.","family":"Langan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Taylor","family":"Ripley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinton D.","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth M.","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford J.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K.","family":"Libutti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tito","family":"Fojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Schrump","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itzhak","family":"Avital","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.01029"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23886"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0716-x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2009.06.019"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198903000-00004"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-999-0719-7"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/13651820500471848"},{"key":"e_1_2_5_9_2","first-page":"972","article-title":"Adrenocortical carcinoma in surgically treated patients: A retrospective study on 156 cases by the French Association of Endocrine Surgeons","volume":"112","author":"Icard P","year":"1992","journal-title":"Surgery"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24331"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11084"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1564-z"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1994.183"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-011-0276-3"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21841"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02067349"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930550306"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(96)80164-4"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931201)72:11<3145::AID-CNCR2820721105>3.0.CO;2-N"},{"key":"e_1_2_5_20_2","first-page":"963","article-title":"An eleven\u2010year experience with adrenocortical carcinoma","volume":"122","author":"Pommier MF","year":"1992","journal-title":"Surgery"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199004263221705"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.23015","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.23015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T18:54:06Z","timestamp":1700592846000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.23015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,20]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1002\/jso.23015"],"URL":"https:\/\/doi.org\/10.1002\/jso.23015","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,20]]}}}