{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:33:00Z","timestamp":1773228780339,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Although sentinel lymph node (SLN) biopsy using radioisotope (RI) and blue dye (BD) achieved a high detection rate, approximately 5% of melanomas with negative SLNs develop nodal metastasis. We tested a new lymphatic navigation method using indocyanine green fluorescence imaging (ICG\u2010FI) to detect such \u201coccult\u201d SLNs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010four skin cancer patients received SLN biopsy with the following three methods: RI (99Tc\u2010tin colloid), BD (2% patent blue), and ICG (0.5% indocyanine green). Lymph nodes detected by any of the three methods were counted as SLNs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ICG\u2010FI detected more SLNs in 8 out of the 34 cases (24%). The average numbers of SLNs detected by ICG\u2010FI, RI, and BD were 2.18, 1.76, and 1.73, respectively. Interestingly, ICG\u2010FI not only detected more SLNs in one basin (ICG\u2010FI: 1.64, RI: 1.50, and BD: 1.51 SLNs per basin), but also detected additional SLNs in other basins (ICG\u2010FI: 1.32, RI: 1.18, and BD: 1.15 basins per case).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ICG\u2010FI detected SLNs more efficiently than did the conventional methods, and these \u201coccult\u201d SLNs may offer an explanation for some false\u2010negative cases. We recommend using ICG\u2010FI in addition to a conventional method to reduce the risk of overlooking these \u201coccult\u201d SLNs. J. Surg. Oncol. 2012; 106:41\u201345. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23045","type":"journal-article","created":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T18:53:51Z","timestamp":1326826431000},"page":"41-45","source":"Crossref","is-referenced-by-count":86,"title":["Indocyanine green fluorescence\u2010navigated sentinel node biopsy showed higher sensitivity than the radioisotope or blue dye method, which may help to reduce false\u2010negative cases in skin 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