{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:21:48Z","timestamp":1760865708373,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T00:00:00Z","timestamp":1327622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001826","name":"Netherlands Organization for Health Research and Development","doi-asserted-by":"crossref","award":["907-06-177"],"award-info":[{"award-number":["907-06-177"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Stichting De Drie Lichten, The Netherlands"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sinusoidal obstruction syndrome (SOS) occurs in 50\u201370% of patients after oxaliplatin treatment for hepatic colorectal metastasis. SOS is associated with portal hypertension and is caused by oxidative damage to endothelial cells and matrix metalloproteinase (MMP) induction. We studied the effect of a flavonoid (monoHER) on SOS prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A monocrotaline (MTC) SOS model was used in rats, with pre\u2010treatment of monoHER. We studied hepatocellular damage and MMP expression. The potential inhibition of oxaliplatin cytotoxicity by monoHER was tested in vitro in colorectal cancer cell lines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MonoHER ameliorated the increase in portal pressure after MCT (72\u2009hr: 7.3\u2009\u00b1\u20092.7\u2009mmHg vs. 11.4\u2009\u00b1\u20093.0\u2009mmHg, <jats:italic>P<\/jats:italic>\u2009=\u20090.016 MCT\u2009+\u2009monoHER vs. MCT, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). MonoHER prevented hepatocellular damage (ALT: 48\u2009hr 42.2\u2009\u00b1\u20093.1\u2009IU\/L vs. 253.4\u2009\u00b1\u2009171.7\u2009IU\/L, <jats:italic>P<\/jats:italic>\u2009=\u20090.034; 72\u2009hr: 46.2\u2009\u00b1\u20094.3\u2009IU\/L vs. 311.9\u2009\u00b1\u2009163.6\u2009IU\/L, MCT\u2009+\u2009monoHER vs. MCT, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The liver damage score was lower in the monoHER group (72\u2009hr: 4.8\u2009\u00b1\u20093.6 vs. 10.3\u2009\u00b1\u20090.5, MCT\u2010monoHER vs. MCT, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) associated with less inflammatory cell infiltration. Livers of MCT treated rats had higher expression of MMP\u20109 when compared to monoHER pairs at 24\u2009hr (<jats:italic>P<\/jats:italic>\u2009=\u20090.016) and 72\u2009hr (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). MonoHER had no effect on in vitro proliferation of colorectal cancer cells when used either alone or in combination with oxaliplatin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MonoHER prevented MCT induced portal hypertension and hepatic injury in rats. J. Surg. Oncol. 2012; 106:72\u201378. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23046","type":"journal-article","created":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T21:58:48Z","timestamp":1327701528000},"page":"72-78","source":"Crossref","is-referenced-by-count":14,"title":["The flavonoid monoHER prevents monocrotaline\u2010induced hepatic sinusoidal injury in rats"],"prefix":"10.1002","volume":"106","author":[{"given":"Tarek","family":"Ezzat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maartje A.J.","family":"van den Broek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis 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