{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T15:27:15Z","timestamp":1746458835148},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T00:00:00Z","timestamp":1333929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2012,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Malignant degeneration of pilonidal sinuses of the sacrococcygeal region is rare but quite serious, as the tumor soon perforates the sacral fascia and becomes adherent to the irregular posterior aspect of the sacrum, making it very difficult, if not impossible, to remove all neoplastic tissue by conventional surgery, hence the high recurrence rate and poor prognosis. A new cryosurgical technique to treat advanced sacrococcygeal pilonidal cancer is herein presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Seven men aged 30\u201375 (mean: 54.4 years) with advanced squamous\u2010cell carcinomas (four primary, three recurrent) arising in sacrococcygeal pilonidal sinuses were treated with open and thick liquid nitrogen spray\u2014two freeze\u2010thaw cycles. Temperature monitoring was made by thermocouples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Local eradication was achieved in all cases; one patient, however, died of metastatic disease 10 months after treatment, without local recurrence. One patient had a recurrence, or a new tumor, 8 years after treatment and was again submitted to aggressive cryosurgery followed by plastic surgery. He was followed for 14 years without recurrence. The follow\u2010up of the remaining six patients ranges between 7 and 18 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To the author's knowledge, this is the first series of carcinomas of sacrococcygeal pilonidal sinuses successfully treated by cryosurgery. J. Surg. Oncol. 2012; 106:504\u2013508. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23108","type":"journal-article","created":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T15:12:46Z","timestamp":1333984366000},"page":"504-508","source":"Crossref","is-referenced-by-count":11,"title":["A curative cryosurgical technique for advanced cancer of sacrococcygeal pilonidal sinuses"],"prefix":"10.1002","volume":"106","author":[{"given":"Jos\u00e9 Carlos","family":"Almeida\u2010Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,9]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"506","article-title":"Carcinoma arising in pilonidal sinus","volume":"193","author":"Pilipshen SJ","year":"1981","journal-title":"Ann Surg"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02234472"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02234181"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1984.tb01209.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-001-0011-y"},{"key":"e_1_2_7_7_2","first-page":"133","article-title":"Carcinoma arising in pilonidal disease\u2014Report of two cases","volume":"14","author":"Kovacevic P","year":"2007","journal-title":"Facta Univ"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-007-0209-y"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-0267-9"},{"key":"e_1_2_7_10_2","first-page":"1","article-title":"Squamous\u2010cell carcinoma on pilonidal disease","volume":"5","author":"Gil A","year":"2006","journal-title":"Kirurgia"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(61)90538-4"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s101510300001"},{"key":"e_1_2_7_13_2","first-page":"87","article-title":"Carcinoma developing in chronic draining cutaneous sinuses and fistulas","volume":"88","author":"McAnally AK","year":"1949","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_7_14_2","first-page":"103","article-title":"Degeneraci\u00f3n cancerosa de un quiste sacro\u2010coxigeo","volume":"9","author":"Baraldi A:","year":"1942","journal-title":"Bol Soc Cir Rosario"},{"key":"e_1_2_7_15_2","first-page":"367","article-title":"Dos casos de epiteliomas de la region sacro\u2010coxigea consecutivos a un quiste pilonidal y a un teratoma presacro","volume":"24","author":"Vara\u2010L\u00f3pez R:","year":"1947","journal-title":"Rev Cl Esp"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195607\/08)9:4<760::AID-CNCR2820090423>3.0.CO;2-1"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1959.03010120030009"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196207000-00027"},{"key":"e_1_2_7_19_2","first-page":"456","article-title":"Un cas d'\u00e9pith\u00e9lioma developp\u00e9 sur un sinus pilonidal","volume":"40","author":"Boutet M:","year":"1969","journal-title":"Laval Med"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930110212"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.58.685.720"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.08.018"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32261.x"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2007.01270.x"},{"key":"e_1_2_7_25_2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/BF02832109","article-title":"Malignizaci\u00f3n de los sinus pilonidales: Tratamiento","volume":"4","author":"Jaime SP","year":"2002","journal-title":"Rev Oncol"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322010000200002"},{"key":"e_1_2_7_27_2","first-page":"211","article-title":"Cryosurgery of advanced cancer of the extremities","volume":"3","author":"Gon\u00e7alves JCA:","year":"1986","journal-title":"Skin Cancer"},{"key":"e_1_2_7_28_2","first-page":"283","article-title":"Cryomastectomy for advanced cancer","volume":"4","author":"Gon\u00e7alves JCA:","year":"1986","journal-title":"Skin Cancer"},{"key":"e_1_2_7_29_2","first-page":"121","volume-title":"Cryosurgery of breast cancer. 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