{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:08Z","timestamp":1786978148035,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T00:00:00Z","timestamp":1334707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science and Technology General Project of Zhejiang Province","award":["2009C33143"],"award-info":[{"award-number":["2009C33143"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>To investigate the clinical value of CDH1 methylation in preoperative peritoneal washes (PPW) from gastric cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CDH1 methylation was detected by real\u2010time methylation specific\u2010PCR in tumor tissues and corresponding PPW from 92 gastric cancer patients, gastric mucosa from 40 chronic gastritis patients and 48 normal persons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CDH1 methylation was found in 75 of 92 (81.5%) gastric cancer tissues, which significantly correlated with size, growth pattern, differentiation, lymphatic invasion, venous invasion, invasion depth, lymph node metastasis, distant metastasis, and TNM stage of tumor (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), but its relationship to age, gender, tumor site, and\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection was not found (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.05). The percentage of CDH1 methylation in PPW was 48.9%, of which the A\u03b6 value of ROC curve was 0.8 compared to that in gastric cancer tissues. Kaplan\u2013Meier analysis showed that there was a significant difference in disease\u2010free survival (DFS) between the patients with or without methylated CDH1 in their PPW (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u2009109.64,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.000). Cox regression analysis revealed CDH1 methylation in PPW was an independent risk factor for gastric cancer patients, with a remarkable decrease in DFS after postoperative 30 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Methylated CDH1 in PPW predicts poor prognosis for gastric cancer patients. J. Surg. Oncol. 2012; 106:765\u2013771. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.23116","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T09:11:14Z","timestamp":1334740274000},"page":"765-771","source":"Crossref","is-referenced-by-count":35,"title":["CDH1 methylation in preoperative peritoneal washes is an independent prognostic factor for gastric 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