{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:32:24Z","timestamp":1790209944449,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,13]],"date-time":"2012-04-13T00:00:00Z","timestamp":1334275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Although the three\u2010field lymphadenectomy has established as a standard operation for esophageal cancer in Japan, criticism remains due to the lack of randomized controlled trials with a high EBM level. This retrospective study aims to clarify the effectiveness of the three\u2010field lymphadenectomy using the data obtained from 906 consecutive patients with esophageal cancer who underwent R0 esophagectomy with the three\u2010field lymphadenectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p><jats:italic>Efficacy Index<\/jats:italic> (<jats:italic>EI<\/jats:italic>) was calculated for each lymph node station and grossly cervical, mediastinal, or abdominal dissection field. The values of <jats:italic>EI<\/jats:italic> were compared according to main tumor location.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cervical lymph node dissection had high <jats:italic>EI<\/jats:italic> in upper and middle thoracic esophageal cancer but it was very small in lower esophageal cancer. Abdominal lymphadenectomy for upper thoracic esophageal cancer had some but limited efficacy only in paracardiac and lesser curvature stations. Cervical lymphadenectomy for lower esophageal cancer showed some but limited efficacy only in cervical paraesophageal stations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our investigation clearly shows the effectiveness and importance of wide range lymph node dissection defined as D3 according to the Japanese N\u2010grouping system for thoracic esophageal cancer. The three\u2010field lymphadenectomy is regarded as a standard procedure for upper and middle thoracic esophageal cancer. J. Surg. Oncol. 2012; 106:742\u2013747. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23122","type":"journal-article","created":{"date-parts":[[2012,4,13]],"date-time":"2012-04-13T13:08:42Z","timestamp":1334322522000},"page":"742-747","source":"Crossref","is-referenced-by-count":150,"title":["The importance of grouping of lymph node stations and rationale of three\u2010field lymphoadenectomy for thoracic esophageal cancer"],"prefix":"10.1002","volume":"106","author":[{"given":"Harushi","family":"Udagawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Shinohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusuke","family":"Haruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Kaida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Tsurumaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,13]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"19","volume-title":"Surgery for Cancer of the Esophagus","author":"Akiyama H:","year":"1990"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-011-0266-8"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-008-0381-1"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2050.2001.00166.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800820321"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-009-0169-0"},{"key":"e_1_2_6_8_2","first-page":"66","volume-title":"TNM classification of malignant tomours","author":"International Union Against Cancer","year":"2009"},{"key":"e_1_2_6_9_2","first-page":"297","article-title":"The results of operations for the cure of cancer of the breast performed at the Johns Hopkins Hospital from June 1889 to January 1894","volume":"4","author":"Halsted W:","year":"1894","journal-title":"Johns Hopkins Hosp Bull"},{"key":"e_1_2_6_10_2","volume-title":"Japanese classification of colorectal carcinoma","author":"Japanese Society for Cancer of the Colon and Rectum","year":"2009"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000172164"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.23122","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.23122","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.23122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T16:43:20Z","timestamp":1700585000000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.23122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,13]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1002\/jso.23122"],"URL":"https:\/\/doi.org\/10.1002\/jso.23122","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,13]]}}}