{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:11:18Z","timestamp":1789182678739,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T00:00:00Z","timestamp":1340755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>The purpose of this study was to estimate the risk factors having relationships with pathologic fracture of osteosarcoma of extremities and to evaluate the role of limb salvage surgery in this group of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 28 consecutive cases of pathologic fracture of primary high\u2010grade localized osteosarcoma of extremities between June 1, 2001 and June 30, 2009. All patients underwent limb salvage surgery and neo\u2010adjuvant chemotherapy. They had a median age of 14 years (range, 6\u201330 years). The average follow\u2010up time was 40.7 months (range, 9\u2013108 months). Clinicopathological factors were analyzed in relation to pathologic fracture. Their recurrence and survival rates were compared to those in cohort of 171 osteosarcoma patients without pathologic fracture who underwent limb salvage surgery during the same period at the same institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Less than 15 years, telangiectatic histological subtype, tumor located at the proximal humerus, and radiographical manifested as osteolytic features were risk factors in relation to pathologic fracture. The overall 3\u2010 and 5\u2010year survival rates were 50.5% and 45.4%, respectively, in the fracture group, and were not significantly different from those in the control group (71.0% and 61.9%, respectively). Of all 28 fracture patients, 4 experienced local recurrences (14.2%) and 14 developed distant metastasis (50%), which were not significantly different from the rates in the control group (8.8% and 37.4%, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Limb salvage surgery with adequate margins combined with neo\u2010adjuvant chemotherapy for pathologic fracture of osteosarcoma did not seem to significantly increase the risk of local recurrence or distal metastasis. J. Surg. Oncol. 2012; 106:820\u2013825. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.23150","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T14:22:39Z","timestamp":1340806959000},"page":"820-825","source":"Crossref","is-referenced-by-count":36,"title":["Pathologic fracture does not influence local recurrence and survival in high\u2010grade extremity osteosarcoma with adequate surgical margins"],"prefix":"10.1002","volume":"106","author":[{"given":"Lu","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanbo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870215)59:4<701::AID-CNCR2820590407>3.0.CO;2-V"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2007.07.018"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198870020-00024"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1302\/0301-620X.78B5.0780694","article-title":"The surgical treatment and outcome of pathological fractures in localised osteosarcoma","volume":"78","author":"Abudu A","year":"1996","journal-title":"J Bone Joint Surg Br"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016470310017776"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.07.004"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/107327480501200107"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200201000-00008"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199603000-00028"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198011000-00013"},{"key":"e_1_2_7_12_2","first-page":"516","article-title":"The improvement of chemotherapy for malignant bone tumor","volume":"24","author":"Tai Qiang Yan WG:","year":"2002","journal-title":"Chin J Oncol"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21979"},{"key":"e_1_2_7_14_2","first-page":"1730","article-title":"The surgical treatment and outcome of nonmetastatic osteosarcoma of the extremity with pathologic fractures","volume":"46","author":"Niu Xiao\u2010hui DY:","year":"2008","journal-title":"Chin J Surg"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002640000143"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21265"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21724"},{"key":"e_1_2_7_18_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/00003086-199109000-00020","article-title":"Telangiectatic osteosarcoma","volume":"270","author":"Mervak TR","year":"1991","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21542"},{"key":"e_1_2_7_20_2","first-page":"575","volume-title":"Prevention management and outcome","author":"Delepine G","year":"1991"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.23150","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.23150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.23150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T06:23:43Z","timestamp":1696919023000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.23150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,27]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1002\/jso.23150"],"URL":"https:\/\/doi.org\/10.1002\/jso.23150","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,27]]}}}