{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:17:20Z","timestamp":1768871840282,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T00:00:00Z","timestamp":1336953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Backgrounds and Objectives<\/jats:title><jats:p>A different classification system was used in the 7th edition of the TNM classification for adenocarcinoma of the subcardia either with or without esophageal invasion. The aim of this study was to clarify the clinicopathological and survival impact of esophageal invasion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study included 351 patients who underwent gastrectomy for adenocarcinoma located within 5\u2009cm of the esophagogastric junction. The clinicopathological characteristics and survival curves were compared between patients with esophageal invasion [E (+) group, n\u2009=\u2009125] and without esophageal invasion [E (\u2212) group, n\u2009=\u2009226].<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients in the E (+) group had more advanced disease. The 5\u2010year survival rate following macroscopic curative resection was significantly better in the E (\u2212) group (80.8%) than in the E (+) (48.7%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), even after stratification by the pathological stage and nodal status. Multivariate analysis identified esophageal invasion (hazard ratio; 3.323, 95% confidential interval; 1.815\u20136.082) as one of the independent prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Esophageal invasion affected the clinicopathological characteristics and long\u2010term outcome of patients. Further study is necessary to clarify whether patients with esophageal invasion should be classified using the system for esophageal cancer or by another method. J. Surg. Oncol. 2012; 106:856\u2013861. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23152","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T13:21:15Z","timestamp":1337001675000},"page":"856-861","source":"Crossref","is-referenced-by-count":4,"title":["Impact of esophageal invasion on clinicopathological characteristics and long\u2010term outcome of adenocarcinoma of the subcardia"],"prefix":"10.1002","volume":"106","author":[{"given":"Masanori","family":"Tokunaga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Tanizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuro","family":"Bando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiichi","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Tsubosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Terashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,14]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05572.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-011-0001-0"},{"key":"e_1_2_5_4_2","first-page":"247","article-title":"Lymphatic drainage routes of the gastric cardia visualized by lymphoscintigraphy","volume":"45","author":"Cense HA","year":"2004","journal-title":"J Nucl Med"},{"key":"e_1_2_5_5_2","volume-title":"TNM Classification of Malignant Tumors","author":"Sobin L","year":"2009"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-002-6776-8"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199706000-00005"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-008-0344-0"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00011681"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1983-x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20987"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0053-z"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(03)00539-8"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200009000-00007"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-010-0555-2"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0247-x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(99)00201-X"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0636-9"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-0434-x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70766-5"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022343"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31815c4037"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.23152","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.23152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.23152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T10:23:50Z","timestamp":1696933430000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.23152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,14]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1002\/jso.23152"],"URL":"https:\/\/doi.org\/10.1002\/jso.23152","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,14]]}}}