{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:01:17Z","timestamp":1791860477820,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T00:00:00Z","timestamp":1338336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2012,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Aim of this study was to analyze (1) survival, local recurrence (LR), and metastasis rates between the three histological tumor grades; (2) whether type of treatment and tumor site influenced prognosis for each histologic grade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively studied 296 patients with central conventional chondrosarcomas (CS) (87 grade 1, 162 grade 2, and 47 grade 3). The femur was the most common site (91 cases), followed by the pelvis (82) and other less frequent sites. Type of surgery was related with histologic grade. Margins were wide in 222 cases, marginal in 23, and intralesional in 51 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At a mean of 7 years, 201 patients remained continuously NED, 33 were NED after treatment of relapse, 15 were AWD, 35 were died of disease, and 12 of other causes. Survival was 92% at 5 years and 84% at 10 years, significantly influenced by histological grading. In grade 3 CS, two factors influenced survival: type of surgery (resection vs. amputation, <jats:italic>P<\/jats:italic>\u2009=\u20090.051) and site (<jats:italic>P<\/jats:italic>\u2009=\u20090.039). The two significant factors lost their significance at multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Central conventional CS with low\/intermediate grade has a good prognosis, while high\u2010grade tumors have poor outcome. Tumor relapses are strictly related with histologic grade. J. Surg. Oncol. 2012; 106: 929\u2013937. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23173","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T14:34:56Z","timestamp":1338388496000},"page":"929-937","source":"Crossref","is-referenced-by-count":176,"title":["Clinical outcome of central conventional chondrosarcoma"],"prefix":"10.1002","volume":"106","author":[{"given":"Andrea","family":"Angelini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas F.","family":"Mavrogenis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Pala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Picci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Ruggieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,30]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"234","volume-title":"World health organization classification of tumours. Pathology and genetics. Tumours of soft tissue and bone","author":"World Health Organization","year":"2002"},{"key":"e_1_2_6_3_2","first-page":"71","volume-title":"Dahlin's bone tumors: General aspects and data on 11,087 cases","author":"Unni KK","year":"1996"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-3846-5"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-003-0896-x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-006-0212-x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.2.5.461"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2007-0237"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002920050130"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(18)30084-4"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.169.4.9308471"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007760170015"},{"key":"e_1_2_6_13_2","first-page":"645","article-title":"Enchondroma and chondrosarcoma of bone: Clinical, radiologic, and histologic differentiation","volume":"53","author":"Weiner SD:","year":"2004","journal-title":"Instr Course Lect"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200110000-00025"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200710000-00003"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322005000200007"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo0000093895.12372.c1"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.87B11.16621"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199301000-00035"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197708)40:2<818::AID-CNCR2820400234>3.0.CO;2-B"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/00003086-198603000-00012","article-title":"Chondrosarcoma","volume":"204","author":"Healey JH","year":"1986","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.18.5.9747616"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-008-0486-z"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/BLO.0b013e318146830f"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0748-7983(98)91459-7"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453679508995543"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-1211-1"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-1056-7"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/BLO.0b013e3180caac2c"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.84B1.0840093"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199903000-00004"},{"key":"e_1_2_6_32_2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/00003086-198512000-00035","article-title":"A new histologic approach to the differentiation of enchondroma and chondrosarcoma of the bones: aA clinicopathologic analysis of 51 cases","volume":"201","author":"Mirra JM","year":"1985","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_6_33_2","first-page":"42","article-title":"Diagnosis of borderline cartilage lesions of bone","volume":"2","author":"Schiller AL:","year":"1985","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31817eec2b"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195205)5:3<551::AID-CNCR2820050317>3.0.CO;2-Z"},{"key":"e_1_2_6_36_2","first-page":"553","article-title":"Chondrosarcoma of bone","volume":"19","author":"Lichtenstein L","year":"1943","journal-title":"Am J Pathol"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198603000-00003"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21979"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.88B9.17896"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1368-7"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1042-3680(18)30088-3"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800601)45:11<2769::AID-CNCR2820451111>3.0.CO;2-X"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(83)80014-0"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70282-5"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-009-0088-2"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820801)50:3<577::AID-CNCR2820500332>3.0.CO;2-G"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-196345070-00010"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198163080-00006"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200009000-00003"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001433-200012000-00009"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010401)91:7<1201::AID-CNCR1120>3.0.CO;2-W"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.H.00416"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2869"},{"key":"e_1_2_6_54_2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1302\/0301-620X.61B4.500746","article-title":"A review of the behaviour of chondrosarcoma of bone","volume":"61","author":"Sanerkin NG","year":"1979","journal-title":"J Bone Joint Surg Br"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981115)83:10<2105::AID-CNCR9>3.0.CO;2-U"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21114"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960815)78:4<745::AID-CNCR9>3.0.CO;2-D"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.90B11.21029"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01208847"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1292::AID-CNCR10>3.0.CO;2-X"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32812143d9"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.23173","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.23173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.23173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T13:10:23Z","timestamp":1700572223000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.23173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,30]]},"references-count":60,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,12,15]]}},"alternative-id":["10.1002\/jso.23173"],"URL":"https:\/\/doi.org\/10.1002\/jso.23173","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,30]]}}}