{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:28:03Z","timestamp":1773408483545,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T00:00:00Z","timestamp":1340150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2012,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Determinants for adequate lymph node yield (LNY) in prophylactic central neck dissection (pCND) for papillary thyroid carcinoma (PTC) remain unclear. We aimed to determine factors affecting LNY in pCND.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of 230 patients, 109 (47.4%) had total thyroidectomy and unilateral pCND. A specimen of \u22656 central lymph nodes (CLNs) was considered adequate. Factors such as patient clinicopathologic features, specimen dimensions, and pathologists' experience were compared between those with LNY\u2009&lt;\u20096 (n\u2009=\u200952) and LNY\u2009\u2265\u20096 (n\u2009=\u200957). A multivariate analysis was conducted to identify independent factors for LNY\u2009\u2265\u20096.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Age, sex, presentation, body mass index, tumor characteristics, <jats:italic>TNM<\/jats:italic> stages, <jats:italic>MACIS<\/jats:italic> score, and pathologist's experience were not significant determinants for LNY\u2009\u2265\u20096. In the univariate analysis, the length (<jats:italic>P<\/jats:italic>\u2009=\u20090.021), width (<jats:italic>P<\/jats:italic>\u2009=\u20090.047), thickness (<jats:italic>P<\/jats:italic>\u2009=\u20090.024), and pN1a (<jats:italic>P<\/jats:italic>\u2009=\u20090.042) were significant determinants but in the multivariate analysis, the length (OR\u2009=\u20091.486 (95% CI: 1.053\u20132.097), <jats:italic>P<\/jats:italic>\u2009=\u20090.024) was the only independent factor for LNY\u2009\u2265\u20096. Postoperative vocal cord palsy, hypoparathyroidism, stimulated thyroglobulin and recurrences were similar between LNY &lt;6 and \u22656.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Length (or the longest measured dimension) of the fresh CLN specimen was the only factor assuring LNY\u2009\u2265\u20096. Surgical complications and short\u2010term outcomes appeared similar between LNY &lt;6 or \u22656. J. Surg. Oncol. 2012; 106: 966\u2013971. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23201","type":"journal-article","created":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T12:46:51Z","timestamp":1340196411000},"page":"966-971","source":"Crossref","is-referenced-by-count":19,"title":["Factors affecting the adequacy of lymph node yield in prophylactic unilateral central neck dissection for papillary thyroid carcinoma"],"prefix":"10.1002","volume":"106","author":[{"given":"Brian Hung\u2010Hin","family":"Lang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Chun\u2010Ling","family":"Yih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony W.\u2010H.","family":"Shek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koon Yat","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai Pun","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung\u2010Yau","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,20]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"Cancer incidence and mortality in Hong Kong 1983\u20132008:Hong Kong Cancer Registry Hong Kong. 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