{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:11:50Z","timestamp":1785813110363,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T00:00:00Z","timestamp":1345680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Biosignature in Colorectal Cancers, Academia Sinica, Taiwan, an Excellence for Cancer Research Center","award":["DOH101-TD-C-111-002"],"award-info":[{"award-number":["DOH101-TD-C-111-002"]}]},{"name":"Kaohsiung Medical University Hospital","award":["KMUH98-8I04, OM16"],"award-info":[{"award-number":["KMUH98-8I04, OM16"]}]},{"name":"National Science Council of the Republic of China NSC","award":["99-2320-B-014-MY3"],"award-info":[{"award-number":["99-2320-B-014-MY3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Angiogenesis plays an important role in the progression of colorectal cancer (CRC). Studies have indicated vascular endothelial growth factor (VEGF) is the predominant angiogenic factor. Cyclin D1 (CCND1) induces production of VEGF and is required for migration of blood vessels. Our aim was to determine the roles of CCND1 and VEGF overexpression in CRC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed clinicopathological features, VEGF and CCND1 expressions by immunohistochemical (IHC) staining in 100 stage I\u2013III CRC patients (44 were postoperative relapsed; 56 were postoperative non\u2010relapsed) to determine the correlation between clinicopathologic features and co\u2010existence of CCND1 and VEGF. Furthermore, the clinical outcomes of co\u2010existence of CCND1 and VEGF were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate analysis showed vascular invasion (<jats:italic>P<\/jats:italic>\u2009=\u20090.019), VEGF overexpression (<jats:italic>P<\/jats:italic>\u2009=\u20090.033), and high postoperative serum carcinoembryonic antigen (CEA) levels (<jats:italic>P<\/jats:italic>\u2009=\u20090.022) were independent predictors of postoperative relapse. Co\u2010existence of CCND1 and VEGF overexpression had significantly poorer disease\u2010free survival rates (<jats:italic>P<\/jats:italic>\u2009=\u20090.004) and overall survival rates (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) than other phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Co\u2010existence of CCND1 and VEGF overexpression would potentially assist in TNM staging systems to predict the prognosis of these patients who would benefit from intensive follow\u2010up and therapeutic programs. J. Surg. Oncol. 2013;107:148\u2013154. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23243","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T17:29:33Z","timestamp":1345742973000},"page":"148-154","source":"Crossref","is-referenced-by-count":17,"title":["Co\u2010existence of cyclin D1 and vascular endothelial growth factor protein expression is a poor prognostic factor for UICC stage I\u2013III colorectal cancer patients after curative 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