{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:37:46Z","timestamp":1773081466923,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T00:00:00Z","timestamp":1370822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Asan Institute for Life Sciences","award":["2011-069"],"award-info":[{"award-number":["2011-069"]}]},{"name":"Korea Health 21 R & D Project","award":["A062254"],"award-info":[{"award-number":["A062254"]}]},{"name":"Centre for Development and Commercialization of Anti-Cancer Therapeutics","award":["A102059"],"award-info":[{"award-number":["A102059"]}]},{"name":"Ministry of Health, Welfare, and Family Affairs, Republic of Korea"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>To identify characteristics of recurrent colorectal cancer in terms of follow\u2010up periods, that is, \u22645 years and &gt;5 years after curative operations<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study enrolled 4,023 patients. Of them, 835 patients showed recurrence after primary curative resection for colorectal cancer. Recurrence occurred \u22645 years (n\u2009=\u2009799) or &gt;5 years (n\u2009=\u200936) after curative surgery. Variables and recurrence patterns were compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 835 patients who experienced recurrence, only 4.3% recurred &gt;5 years after surgery. This group showed lower preoperative serum carcinoembryonic antigen levels, more tumors with expanding growth, well\u2010differentiated histology, and no lymph node metastasis (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In terms of haematogenous metastasis, lung or liver was the most prevalent site in patients who recurred after &gt;5 years or \u22645 years, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.005). In rectal cancer patients, recurrence patterns revealed the same results. In colon cancer patients, the liver was the most prevalent site in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After 5 years of follow\u2010up, routine surveillance for detecting other malignancies seems to be sufficient. However, the possibility of late (particularly late pulmonary) recurrence should be considered. Radiologic examination to detect pulmonary metastasis should be considered in the follow\u2010up program. <jats:italic>J. Surg. Oncol. 2013;108:9\u201313<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23349","type":"journal-article","created":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T11:44:42Z","timestamp":1370864682000},"page":"9-13","source":"Crossref","is-referenced-by-count":102,"title":["Comparison of recurrence patterns between \u22645 years and &gt;5 years after curative operations in colorectal cancer patients"],"prefix":"10.1002","volume":"108","author":[{"given":"Seok In","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Surgery University of Ulsan College of Medicine and Asan Medical Centre Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok\u2010Byung","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Ulsan College of Medicine and Asan Medical Centre Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Sik","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Ulsan College of Medicine and Asan Medical Centre Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Ulsan College of Medicine and Asan Medical Centre Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Sik","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Ulsan College of Medicine and Asan Medical Centre Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Internal Medicine University of Ulsan College of Medicine and Asan Medical Centre Seoul Republic of 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