{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:50:00Z","timestamp":1768683000899,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T00:00:00Z","timestamp":1379980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the prognostic value of total tumor volume (TTV) in patients with laryngeal and hypopharyngeal carcinomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study involved 182 patients with previously untreated advanced\u2010stage squamous cell carcinoma of the larynx or hypopharynx. TTV were calculated from pretreatment contrast\u2010enhanced computed tomography images. Univariate and multivariate analyses were used to identify factors associated with overall (OS), disease\u2010specific (DSS), and disease\u2010free survival (DFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At a median follow\u2010up of 63 months (range, 24\u2013139 months), the 5 year OS, DSS, and DFS rates were 60.2%, 73.1%, and 69.4%, respectively. Multivariate analyses showed that tumor site was an independent predictor of DSS (<jats:italic>P<\/jats:italic>\u2009=\u20090.03); Charlson comorbidity index for OS (<jats:italic>P<\/jats:italic>\u2009=\u20090.001); second primary cancer for OS (<jats:italic>P<\/jats:italic>\u2009=\u20090.008) and DFS (<jats:italic>P<\/jats:italic>\u2009=\u20090.001); and vocal fold paralysis for DSS (<jats:italic>P<\/jats:italic>\u2009=\u20090.014) and DFS (<jats:italic>P<\/jats:italic>\u2009=\u20090.033). Extension to the tongue base was an independent predictor of OS (<jats:italic>P<\/jats:italic>\u2009=\u20090.007), DSS (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and DFS (<jats:italic>P<\/jats:italic>\u2009=\u20090.017), and TTV \u22658.38\u2009ml was an independent predictor of all three survivals (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 each).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Radiologically determined TTV is prognostic of survival in patients with advanced\u2010stage laryngeal and hypopharyngeal carcinoma.<jats:italic>J. Surg. Oncol. 2013; 108:509\u2013515<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23444","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T21:53:00Z","timestamp":1381528380000},"page":"509-515","source":"Crossref","is-referenced-by-count":23,"title":["Prognostic value of total tumor volume in advanced\u2010stage laryngeal and hypopharyngeal carcinoma"],"prefix":"10.1002","volume":"108","author":[{"given":"Chan\u2010Joo","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae\u2010Yoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Asan Medical Center, University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology Asan Medical Center, University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u2010Lyel","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon Yuhl","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Yoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"},{"name":"Biomedical Research Institute Korea Institute of Science and Technology Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,24]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"21","volume-title":"American Joint Committee of Cancer\u2014AJCC Cancer Staging Manual","author":"Edge SBB","year":"2010"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20556"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/hed.21459","article-title":"Tumor volume as prognostic factor in chemoradiation for advanced head and neck cancer","volume":"33","author":"Knegjens JL","year":"2010","journal-title":"Head Neck"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00626-8"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)01559-5"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00031-S"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10030"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199803)20:2<159::AID-HED10>3.0.CO;2-H"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860600815407"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21011"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200210000-00006"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.11.001"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00039-5"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3656-4_4"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.177.2.2217772"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-006-0490-0"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk179"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.4.242"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.05.022"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21361"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/028418698430467"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000091803"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.23444","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.23444","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.23444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T16:35:14Z","timestamp":1716050114000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.23444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,24]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1002\/jso.23444"],"URL":"https:\/\/doi.org\/10.1002\/jso.23444","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,24]]}}}