{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:46:21Z","timestamp":1790023581496,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T00:00:00Z","timestamp":1381881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Our goal was to evaluate the different subtypes of mucosal melanoma and describe specific variables that predict outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective review of two tertiary care center databases identified 76 mucosal melanoma patients; 73 with complete records were included. Demographic and clinical data were analyzed. Cox regression determined variables impacting recurrence and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the 73 patients, the mean age was 64 years, and 74% were female. Sixty\u2010seven percent presented with lymph node involvement, and 73% had ulcerated tumors. Major sites affected were nasal\/palate\/oral (36%), vulvar\/vaginal\/cervical (48%), and anorectal (15%). Mean overall and disease\u2010free survival were 56.9 and 27.2 months. Variables associated with decreased survival included: lymphovascular invasion (HR17.70, <jats:italic>P<\/jats:italic>\u2009=\u20090.0093), Caucasian race (HR3.02, <jats:italic>P<\/jats:italic>\u2009=\u20090.0362), nasal\/palate\/oral sub\u2010group (HR1.85, <jats:italic>P<\/jats:italic>\u2009=\u20090.026), Breslow thickness (HR1.23, <jats:italic>P<\/jats:italic>\u2009=\u20090.00004), T stage (HR1.34, <jats:italic>P<\/jats:italic>\u2009=\u20090.0075), M stage (HR3.03, <jats:italic>P<\/jats:italic>\u2009=\u20090.0039), and chemotherapy (HR3.13, <jats:italic>P<\/jats:italic>\u2009=\u20090.0002). The worst prognosis was seen in the nasal\/palate\/oral sub\u2010group, with a median overall survival of 9.7 months and recurrence\u2010free time of 4.5 months. This subtype also demonstrated high lymph node positivity, ulceration, and larger tumor size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The nasal, palate, oral subtype has the worst prognosis compared to other mucosal melanoma locations. Studies are ongoing to evaluate pathologic and genomic variables that may predict outcomes. <jats:italic>J. Surg. Oncol. 2013; 108:516\u2013520<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23445","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T14:34:57Z","timestamp":1381934097000},"page":"516-520","source":"Crossref","is-referenced-by-count":33,"title":["Outcomes in patients with mucosal melanomas"],"prefix":"10.1002","volume":"108","author":[{"given":"Deborah S.","family":"Keller","sequence":"first","affiliation":[{"name":"Department of Surgery Temple University School of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan A.","family":"Thomay","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Fox Chase Cancer Center Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gaughan","sequence":"additional","affiliation":[{"name":"Biostatistics Consulting Center Temple University 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