{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T08:31:18Z","timestamp":1720427478462},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T00:00:00Z","timestamp":1382659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Our aim was to analyze clinicopathologic and prognostic values of microRNA (miR)\u2010218 in pancreatic ductal adenocarcinima (PDAC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>TaqMan quantitative RT\u2010PCR was used to determine the expression of miR\u2010218 in human PDAC cells and tissue samples. The association of miR\u2010218 expression with clinicopathologic variables was analyzed. Kaplan\u2013Meier survival analysis was performed to analyze the association of miR\u2010218 expression with recurrence\u2010free survival or overall survival of patients. Univariate and multivariate Cox regression analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The relative level of miR\u2010218 in PDAC cells was significantly lower than that in normal human pancreatic duct epithelial cell line. Also, the mean level of miR\u2010218 in PDAC tissues was significantly lower than that in normal pancreatic tissues. Statistical analyses indicated that low miR\u2010218 expression was closely associated with poor tumor differentiation, advanced tumor stage, higher incidence of lymph node metastasis, and tumor recurrence. Kaplan\u2013Meier survival analyses showed that patients with low miR\u2010218 expression had lower recurrence\u2010free and overall survival than those with high miR\u2010218 expression. Univariate and multivariate Cox regression analyses showed that miR\u2010218 might be an independent prognostic factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduced miR\u2010218 in PDAC tissues was correlated with tumor progression, and might be an independent poor prognostic factor for patients. <jats:italic>J. Surg. Oncol. 2014 109:89\u201394<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23475","type":"journal-article","created":{"date-parts":[[2013,10,26]],"date-time":"2013-10-26T03:56:42Z","timestamp":1382759802000},"page":"89-94","source":"Crossref","is-referenced-by-count":24,"title":["Expression of microRNA\u2010218 in human pancreatic ductal adenocarcinoma and its correlation with tumor progression and patient survival"],"prefix":"10.1002","volume":"109","author":[{"given":"Ziman","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery First Hospital Affiliated to the Chinese PLA General Hospital Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuefang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy First Hospital Affiliated to the Chinese PLA General Hospital Beijing People's Republic of 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