{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T20:49:45Z","timestamp":1772052585834,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,7]],"date-time":"2013-12-07T00:00:00Z","timestamp":1386374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ajou University Graduate School Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Metastatic colon cancer patients are treated with the chemotherapy regimens, FOLFOX and FOLFIRI, in either order. So far, we cannot predict the response of chemotherapeutic agent, so it is necessary to find which regimen is adequate before starting chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Enrolled patients are randomized into either conventional treatment or planned treatment preceded by pretreatment genetic analysis. Blood samples of patients in planned treatment group (N\u2009=\u200953) were analyzed for the genetic polymorphism before selection of chemotherapeutic agents. Target genes were XPD\u2010751, GSTP\u20101\u2010105, XRCC1\u2010399 for oxaliplatin, UGT1A1 for irinotecan. The response was measured by computed tomographic scan after completion of three cycles of chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall response rate was significantly higher in planned group (67.9% vs. 46.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.020). In FOLFOX group, response rate was significantly improved in the planned patients(77.1% vs. 50%, <jats:italic>P<\/jats:italic>\u2009=\u20090.018). In FOLFIRI group, the difference didn't reach statistical significance (50% vs. 42.5%, <jats:italic>P<\/jats:italic>\u2009=\u20090.776).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found significantly improved response rates in the chemotherapy of metastatic colon cancer by pretreatment genetic analysis, especially in FOLFOX group. <jats:italic>J. Surg. Oncol. 2014 109:250\u2013254<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23500","type":"journal-article","created":{"date-parts":[[2013,12,7]],"date-time":"2013-12-07T11:51:13Z","timestamp":1386417073000},"page":"250-254","source":"Crossref","is-referenced-by-count":9,"title":["Pretreatment selection of regimen according to genetic analysis improves the efficacy of chemotherapy in the first line treatment of metastatic colorectal cancer"],"prefix":"10.1002","volume":"109","author":[{"given":"Do Yoon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Surgery Ajou University School of Medicine Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Yoon","family":"Paek","sequence":"additional","affiliation":[{"name":"Department of Surgery Ajou University School of Medicine Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Yeop","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Surgery Ajou University School of Medicine Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Bae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Ajou University School of Medicine Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology Ajou University School of Medicine Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi Young","family":"Lee","sequence":"additional","affiliation":[{"name":"ISU ABXIS Co., Ltd. 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